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  1. Active and passive theories have been advanced to explain splenomegaly and cytopenias in liver disease. Dameshek proposed active downregulation of hematopoiesis. Doan proposed passive trapping of blood compone...

    Authors: John M. Gemery, Andrew R. Forauer, Anne M. Silas and Eric K. Hoffer

    Citation: BMC Hematology 2016 16:3

    Content type: Debate

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  2. Patients receiving anticoagulant drugs must be carefully screened for drug-related problems, as such medications, including warfarin have narrow therapeutic ranges and a high potential for complications. Thus,...

    Authors: Fekede Bekele Daba, Fisihatsion Tadesse and Ephrem Engidawork

    Citation: BMC Hematology 2016 16:2

    Content type: Research article

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  3. Tuberculosis (TB) treatment may present significant hematological disorder and some anti-TB drugs also have serious side effects. Although many other diseases may be reflected by the blood and its constituents...

    Authors: Eyuel Kassa, Bamlaku Enawgaw, Aschalew Gelaw and Baye Gelaw

    Citation: BMC Hematology 2016 16:1

    Content type: Research article

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  4. High levels of fetal haemoglobin (HbF) decrease sickle cell anaemia (SCA) severity and leads to improved survival. According to in vivo and in vitro studies, butyrate increases HbF production. Its utilization ...

    Authors: Lamis Kaddam, Imad FdleAlmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mustafa Elnimeiri, Florian Lang and Amal M. Saeed

    Citation: BMC Hematology 2015 15:19

    Content type: Research article

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  5. Direct oral anticoagulants (DOACs) are now standard of care for the management of thromboembolic risk. A prevalent issue of concern is how to manage direct oral anticoagulant (DOAC)-associated bleeding for whi...

    Authors: Michelle Sholzberg, Katerina Pavenski, Nadine Shehata, Christine Cserti-Gazdewich and Yulia Lin

    Citation: BMC Hematology 2015 15:18

    Content type: Research article

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  6. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with erythrocyte sensitivity to oxidative damage and hemolytic crises. In β-thalassemia major, where hemoglobin instability imposes oxidative s...

    Authors: Mohammad Al-Ansari and James D. Craik

    Citation: BMC Hematology 2015 15:17

    Content type: Research article

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  7. Patients who require transfusion as part of their clinical management have the right to expect sufficient blood to be available to meet their needs and to receive the safest blood possible. Donor deferrals (di...

    Authors: Samuel Antwi-Baffour, David Kwasie Annor, Jonathan Kofi Adjei, Ransford Kyeremeh, George Kpentey and Foster Kyei

    Citation: BMC Hematology 2015 15:15

    Content type: Research article

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  8. Anaemia is a major public health problem in developing countries, contributing significantly to morbidity and mortality amongst children under-five years of age. About 43 % of under-fives are anaemic worldwide...

    Authors: Rehema H. Simbauranga, Erasmus Kamugisha, Adolfine Hokororo, Benson R. Kidenya and Julie Makani

    Citation: BMC Hematology 2015 15:13

    Content type: Research article

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  9. Anemia is the most common hematological abnormalities in HIV patients and it is a wide spread public health problem. The World Health Organization estimates that over 2 billion people are anemic worldwide with...

    Authors: Bamlaku Enawgaw, Meseret Alem, Mulugeta Melku, Zelalem Addis, Betelihem Terefe and Gashaw Yitayew

    Citation: BMC Hematology 2015 15:12

    Content type: Research article

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  10. Each year in the UK, ≈3000 children undergo major cardiac surgery requiring cardiopulmonary bypass. Approximately 40 % of these experience excessive bleeding necessitating red cell transfusion or treatment wit...

    Authors: Wendy Underwood, Chris A. Rogers, Zoe Plummer, Barnaby C Reeves, Massimo Caputo, Peter Murphy, Karen Sheehan, Jessica Harris, Lucy Culliford and Andrew Mumford

    Citation: BMC Hematology 2015 15:11

    Content type: Study protocol

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  11. Isolation of bone marrow cells, including hematopoietic stem cells, is a commonly used technique in both the research and clinical settings. A quantitative and qualitative assessment of cell populations isolat...

    Authors: Maya M. Mahajan, Betty Cheng, Ashley I. Beyer, Usha S. Mulvaney, Matt B. Wilkinson, Marina E. Fomin and Marcus O. Muench

    Citation: BMC Hematology 2015 15:9

    Content type: Research article

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  12. Valacyclovir has been used for prophylaxis against cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT). We investigated the efficacy and safety of high-dose Valacyclovir as pre...

    Authors: Shin-Yeu Ong, Ha-Thi-Thu Truong, Colin Phipps Diong, Yeh-Ching Linn, Aloysius Yew-Leng Ho, Yeow-Tee Goh and William Ying-Khee Hwang

    Citation: BMC Hematology 2015 15:8

    Content type: Research article

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  13. Ethiopia is one of the most seriously HIV affected countries in Sub-Saharan Africa. Anemia is a known predictor of disease progression and death among HIV infected patients. In this study, we investigated the ...

    Authors: Muluken Assefa, Woldaregay Erku Abegaz, Aster Shewamare, Girmay Medhin and Mulugeta Belay

    Citation: BMC Hematology 2015 15:6

    Content type: Research article

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  14. Although prophylaxis is a standard of care for young children in developed countries, known to reduce the severity of hemophilic arthropathy, older adults with existing arthropathy have not traditionally used ...

    Authors: Shannon C Jackson, Ming Yang, Leonard Minuk, Michelle Sholzberg, Jean St-Louis, Alfonso Iorio, Robert Card and Man-Chiu Poon

    Citation: BMC Hematology 2015 15:4

    Content type: Research article

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  15. Severe congenital neutropenia (SCN) is an immunodeficiency disease characterized low blood neutrophil counts, early bacterial infections, and risk of leukaemia development. Heterozygous mutations in the ELANE gen...

    Authors: Quang Van Vu, Taizo Wada, Tham Thi Tran, Duc Ngoc Ngo, Thuc Van Dinh, Cuong Hung Nguyen, Huong Thi Minh Le, Akihiro Yachie and Sang Ngoc Nguyen

    Citation: BMC Hematology 2015 15:2

    Content type: Case report

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  16. Hemophilia A (HA) is an X-linked inherited bleeding disorder, resulting from a qualitative or quantitative deficiency of clotting factor VIII (FVIII). Antibodies against FVIII, also called inhibitors, block th...

    Authors: Amanda CO Silveira, Marcio AP Santana, Isabella G Ribeiro, Daniel G Chaves and Olindo A Martins-Filho

    Citation: BMC Hematology 2015 15:1

    Content type: Research article

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  17. Reliable central venous access (CVC) is essential for hematology–oncology patients since frequent puncture of peripheral veins—e.g., for chemotherapy, antibiotic administration, repeated blood sampling, and mo...

    Authors: Verena Wiegering, Sophie Schmid, Oliver Andres, Clemens Wirth, Armin Wiegering, Thomas Meyer, Beate Winkler, Paul G Schlegel and Matthias Eyrich

    Citation: BMC Hematology 2014 14:18

    Content type: Research article

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  18. Mast cell leukemia (MCL) is rare type of neoplasia with an incidence of 1% in a large series of 342 adult patients with systemic mastocytosis (SM). Chronic basophilic leukemia (CBL) is an extremely rare type o...

    Authors: Cavit Cehreli, Inci Alacacioglu, Ozden Piskin, Halil Ates, Ruksan Cehreli, Gizem Calibasi, Erdinc Yuksel, Sermin Ozkal and Guner H Ozsan

    Citation: BMC Hematology 2014 14:17

    Content type: Case report

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  19. Abnormal hemograms are common manifestations and important predictive tools for morbidity in the human immunodeficiency virus (HIV) infection. Few studies have been reported on the blood profile of HIV antiret...

    Authors: Paul Nji Wankah, Claude Tayou Tagny and Dora Ngum Shu Mbanya

    Citation: BMC Hematology 2014 14:15

    Content type: Research article

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  20. We have previously shown that lymphopenia and monocytopenia at 2–3 months post-allogeneic haematopoietic cell transplant (HCT) is associated with poor survival in recipients of both myeloablative and reduced i...

    Authors: Mary D Thoma, Jennifer Glejf, Eapen Jacob, Tanya J Huneke, Lori J DeCook, Nicci D Johnson, Mrinal M Patnaik, Mark R Litzow, William J Hogan, Laura F Newell, Rekha Chandran, Luis F Porrata and Shernan G Holtan

    Citation: BMC Hematology 2014 14:14

    Content type: Research article

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  21. Anemia is one of the major public health problems affecting more than half of school-age children in developing countries. Anemia among children has been conclusively seen to delay psychomotor development, poo...

    Authors: Bekele Gutema, Wondimagegn Adissu, Yaregal Asress and Lealem Gedefaw

    Citation: BMC Hematology 2014 14:13

    Content type: Research article

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  22. Patients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D (25(OH)D) – compared to controls. Average serum 25(OH)D levels are also substant...

    Authors: Bamidele O Tayo, Titilola S Akingbola, Babatunde L Salako, Colin A McKenzie, Marvin Reid, Jennifer Layden, Ifeyinwa Osunkwo, Jacob Plange-Rhule, Amy Luke, Ramon Durazo-Arvizu and Richard S Cooper

    Citation: BMC Hematology 2014 14:12

    Content type: Research article

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  23. The clinical characteristics of Latin American children enrolled in the International Collaborative Gaucher Group Gaucher Registry at the time of first enzyme therapy infusion (baseline) were investigated, wit...

    Authors: Jose Simon Camelo Jr, Juan Francisco Cabello, Guillermo G Drelichman, Marcelo M Kerstenetzky, Isabel C Sarmiento, Soledad Suarez Ordoñez, John S Taylor, Andrea R Gwosdow and Adriana Linares

    Citation: BMC Hematology 2014 14:10

    Content type: Research article

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  24. Clonal expansions of CD4 positive T large granular lymphocytes with or without co-expression of CD8 are extremely uncommon. These typically display an indolent clinical course and are said to be associated wit...

    Authors: Deepti Mutreja, Rahul Kumar Sharma, Mrinalini Kotru and Renu Saxena

    Citation: BMC Hematology 2014 14:9

    Content type: Case report

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  25. Anemia, leucopenia and thrombocytopenia are the commonest hematological abnormalities resulting from human immunodeficiency virus infection. The use of antiretroviral drugs could positively or negatively affec...

    Authors: Bamlaku Enawgaw, Meseret Alem, Zelalem Addis and Mulugeta Melku

    Citation: BMC Hematology 2014 14:8

    Content type: Research article

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  26. Chronic graft-versus-host disease (cGVHD) is a major factor of morbidity and mortality for allogeneic stem cell transplantation (aSCT). The skin and internal organ involvement is the most common systemic compl...

    Authors: Dmitry N Grigoryev, Jignesh Dalal, Mara L Becker and Shui Q Ye

    Citation: BMC Hematology 2014 14:7

    Content type: Technical advance

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  27. Interleukin-6 (IL-6) is a multifunctional cytokine that is produced by many different cell types, and plays an important role in the regulation of inflammation, immune responses, the acute-phase response, and ...

    Authors: Hiroko Nakagawa, Takashi Tamura, Yoko Mitsuda, Yasuyuki Goto, Yoshikazu Kamiya, Takaaki Kondo, Kenji Wakai and Nobuyuki Hamajima

    Citation: BMC Hematology 2014 14:6

    Content type: Research article

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  28. Transfusion-transmissible infections (TTIs) pose a major health risk in Cameroon given the high prevalence of such pathogens and increased demands for blood donations in the local communities. This study aims ...

    Authors: Carole Else Eboumbou Moukoko, Françoise Ngo Sack, Estelle Géraldine Essangui Same, Madeleine Mbangue and Léopold Gustave Lehman

    Citation: BMC Hematology 2014 14:5

    Content type: Research article

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  29. Alpha-thalassemia is the most common human genetic disease worldwide. Copy number variations in the form of deletions of α-globin genes lead to α-thalassemia while duplications of α-globin genes can cause a se...

    Authors: Runa M Grimholt, Petter Urdal, Olav Klingenberg and Armin P Piehler

    Citation: BMC Hematology 2014 14:4

    Content type: Technical advance

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    The Correction to this article has been published in BMC Hematology 2019 19:13

  30. Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder characterized by immune deficiency, microcephaly, mental retardation and a disposition for the development of hematological ma...

    Authors: Katharina Engel, Martina Rudelius, Felix G Meinel, Christian Peschel and Ulrich Keller

    Citation: BMC Hematology 2014 14:2

    Content type: Case report

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  31. The editors of BMC Hematology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).

    Authors: Peter O'Donovan

    Citation: BMC Hematology 2014 14:1

    Content type: Reviewer acknowledgement

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  32. Complete blood count (CBC) and reticulocyte (Retics) are routine hematology tests useful for the differential diagnosis of anemia and other medical conditions. However, it has been presumed that they are not u...

    Authors: Misganaw Birhaneselassie, Asaye Birhanu, Amha Gebremedhin and Aster Tsegaye

    Citation: BMC Blood Disorders 2013 13:11

    Content type: Research article

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  33. Peripheral pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leucopenia and thrombocytopenia resulting from a number of disease processes. Only a few systematic stud...

    Authors: Arvind Jain and Manjiri Naniwadekar

    Citation: BMC Blood Disorders 2013 13:10

    Content type: Research article

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  34. Prior to diagnosis, patients with haematological cancers often have multiple primary care consultations, resulting in diagnostic delay. They are less likely to be referred urgently to hospital and often presen...

    Authors: Debra A Howell, Alexandra G Smith, Andrew Jack, Russell Patmore, Una Macleod, Emma Mironska and Eve Roman

    Citation: BMC Blood Disorders 2013 13:9

    Content type: Research article

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  35. Anaemia is a common complication of infection with the human immunodeficiency virus (HIV) and may have various causes. The aim of this study was to determine the prevalence and related factors of anemia in HAA...

    Authors: Getachew Ferede and Yitayih Wondimeneh

    Citation: BMC Blood Disorders 2013 13:8

    Content type: Research article

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  36. Congenital hemangiomas are benign abnormal proliferation of blood vessels. Noninvoluting congenital hemangiomas are a rare variant which persist, and may become bigger. Hemangiomas are known to be associated w...

    Authors: Mitrakrishnan C Shivanthan, Bandula Wijesiriwardena and Indira S Wijesiriwardena

    Citation: BMC Blood Disorders 2013 13:7

    Content type: Case report

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  37. Anemia is a common problem in diabetic patients. Diabetic patients have a greater severity of anemia as the level of Glomerular Filtration Rate (GFR) decreases compared to non-diabetic patients. Despite these ...

    Authors: Alemayehu Abate, Wubet Birhan and Abebe Alemu

    Citation: BMC Blood Disorders 2013 13:6

    Content type: Research article

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  38. A 14-month prospective longitudinal study conducted in the Taabo health demographic surveillance system (HDSS), south-central Côte d’Ivoire, revealed high prevalence of anemia in different population groups in...

    Authors: M’Bra KD Kouadio, Aurélie A Righetti, Noël N Abé, Rita Wegmüller, Mitchell G Weiss, Eliézer K N’Goran and Jürg Utzinger

    Citation: BMC Blood Disorders 2013 13:5

    Content type: Research article

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  39. Hypogammaglobulinemia may be part of several different immunological or malignant conditions, and its origin is not always obvious. Furthermore, although autoimmune cytopenias are known to be associated with c...

    Authors: Trine H Mogensen, Jens Magnus Bernth-Jensen, Charlotte C Petersen, Mikkel S Petersen, Charlotte Nyvold, Karsten H Gadegaard, Marianne Hokland, Peter Hokland and Carsten S Larsen

    Citation: BMC Blood Disorders 2013 13:4

    Content type: Case report

    Published on:

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