Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry. 1991;30 Suppl 43:10363–70.
Article
CAS
PubMed
Google Scholar
Fischer K, Van Den Berg M. Prophylaxis for severe haemophilia: clinical and economical issues. Haemophilia. 2003;9 Suppl 4:376–81.
Article
CAS
PubMed
Google Scholar
Spiegel PCJ, Stoddard BL. Optimization of factor VIII replacement therapy: Can structural studies help in evading antibody inhibitors? Br J Haematol. 2002;119 Suppl 2:310–22.
Article
PubMed
Google Scholar
Wight J, Paisley S. The epidemiology of inhibitors in haemophilia A: a systematic review. Haemophilia. 2003;9 Suppl 4:418–35.
Article
CAS
PubMed
Google Scholar
Agostini D, Rosset C, Botton MR, Kappel DB, Vieira IA, Gorziza RP, et al. Immune system polymorphisms and factor VIII inhibitor formation in Brazilian haemophilia A severe patients. Haemophilia. 2012;18 Suppl 6:416–8.
Article
Google Scholar
Lollar P. Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX. J Thromb Haemost. 2004;2 Suppl 7:1082–95.
Article
CAS
PubMed
Google Scholar
Reding MT, Lei S, Lei H, Green D, Gill J, Conti-Fine BM. Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired haemophilia patients. Thromb Haemost. 2002;88 Suppl 4:568–75.
CAS
PubMed
Google Scholar
Hu G, Guo D, Key NS, Conti-Fine BM. Cytokine production by CD4+ T cells specific for coagulation factor VIII in healthy subjects and haemophilia A patients. Thrombd Haemost. 2007;97 Suppl 5:788–94.
CAS
Google Scholar
Astermark J, Oldenburg J, Carlson J, Pavlova A, Kavakli K, Berntorp E, et al. Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood. 2006;108 Suppl 12:3739–45.
Article
CAS
PubMed
Google Scholar
Astermark J, Oldenburg J, Pavlova A, Berntorp E, Lefvert AK, Mibs Study Group. Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A. Blood. 2006;107 Suppl 8:3167–72.
Article
CAS
PubMed
Google Scholar
Chaves DG, Belisario AR, Castro G, Santoro MM, Velloso-Rodrigues C. Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A. Int J Immunogenet. 2010;37 Suppl 2:79–82.
Article
CAS
PubMed
Google Scholar
Chaves DG, Velloso-Rodrigues C, Oliveira CA, Santoro MM, Martins-Filho AO. A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in haemophilia A patients. Clin Exp Immunol. 2010;162 Suppl 3:425–37.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nerich V, Tissot E, Faradji A, Demesmay K, Bertrand MA, Lorenzini JL, et al. Cost-of-illness study of severe haemophilia A and B in five French haemophilia treatment centres. Pharm World Sci. 2008;30:287–92.
Article
PubMed
Google Scholar
Epstein J, Xiong Y, Woo P, Li-Mcleod J, Spotts G. Retrospective analysis of differences in annual factor VIII utilization among haemophilia A patients. Haemophilia. 2012;18:187–92.
Article
CAS
PubMed
Google Scholar
Matsutani T, Sakurai Y, Yoshioka T, Tsuruta Y, Suzuki R, Shima M, et al. Replacement therapy with plasma-derived factor VIII concentrates induces skew in T-cell receptor usage and clonal expansion of CD8+ T-cell in HIV-seronegative hemophilia patients. Thromb Haemost. 2003;90:279–92.
CAS
PubMed
Google Scholar
Gouw SC, Van Den Berg HM, Le Cessie S, Van Der Bom JG. Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A. J Thromb Haemost. 2007;5:1383–90.
Article
CAS
PubMed
Google Scholar
Gouw SC, Van Der Bom J, Van Den Berg HM. Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study. Blood. 2007;109 Suppl 11:4648–54.
Article
CAS
PubMed
Google Scholar
Van Helden PMW, Van Haren SD, Fijnvandraat K, Van Den Berg HM, Voorberg J. Factor VIII-specific B cell responses in haemophilia A patients with inhibitors. Haemophilia. 2010;16:35–43.
Article
PubMed
Google Scholar
Sakurai Y, Matsutani T, Yoshioka T, Takeda T, Yoshioka A, Shima M. Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors. Vojnosanit Pregl. 2011;68 Suppl 12:1047–50.
Article
PubMed
Google Scholar
Oliveira CA, Velloso-Rodrigues C, Machado FC, Carvalho BN, Gentz SH, Martins-Filho OA, et al. Cytokine profile and FVIII inhibitors development in haemophilia A. Haemophilia. 2013;19 Suppl 3:139–42.
Article
Google Scholar
Pimentel JP, Chaves DG, Araújo AR, de Araújo EM, da Silva F, Neves WL, et al. Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with hepatitis C virus. J Med Virol. 2013;85 Suppl 6:1009–18.
Article
PubMed
Google Scholar
Van Helden PMW, Van Den Berg HM, Gouw SC, Kaijen PH, Zuurveld MG, Mauser-Bunschoten EP, et al. IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A. Br J Haematol. 2008;142 Suppl 4:644–52.
Article
PubMed
Google Scholar
Kasama T, Miwa Y, Isozaki T, Odai T, Adachi M, Kunkel SL. Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy. 2005;4 Suppl 3:273–9.
Article
CAS
PubMed
Google Scholar
Hatanaka E, Monteagudo PT, Marrocos MS, Campa A. Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes. Clin Exp Immunol. 2006;146 Suppl 3:443–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wright HL, Moots RJ, Bucknall RC, Edwards RC. Neutrophil function in inflammation and inflammatory diseases. Rheumatology (Oxford). 2010;49 Suppl 9:1618–31.
Article
CAS
Google Scholar
Wroblewska A, Reipert BM, Pratt KP, Voorberg J. Dangerous liaisons: how the immune system deals with factor VIII. J Thromb Haemost. 2013;11:47–55.
Article
CAS
PubMed
Google Scholar
Le Gal FA, Riteau B, Sedlik C, Khalil-Daher I, Menier C, Dausset J, et al. HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes. Int Immunol. 1999;11:1351–6.
Article
PubMed
Google Scholar
Endharti AT, Rifa’I M, Shi Z, Fukuoka Y, Nakahara Y, Kawamoto Y, et al. Cutting Edge: CD8CD122 Regulatory T Cells Produce IL-10 to Suppress IFN Production and Proliferation of CD8 T Cells. J Immunol. 2005;175:7093–7.
Article
CAS
PubMed
Google Scholar
Shi Z, Okuno Y, Rifa’I M, Endharti AT, Akane K, Isobe K, et al. Human CD8CXCR3 T cells have the same function as murine CD8CD122 Treg. Eur J Immunol. 2009;39:2106–19.
Article
CAS
PubMed
Google Scholar
Herndon JM, Stuart PM, Ferguson TA. Peripheral Deletion of Antigen-Specific T Cells Leads to Long-Term Tolerance Mediated by CD8 Cytotoxic Cells. J Immunol. 2005;174:4098–104.
Article
CAS
PubMed
Google Scholar
Dianzani U, Pileri A, Bianchi A, Camponi A, Tamponi G, Massaia M. Biochemical and immunologic abnormalities in peripheral blood T lymphocytes of patients with hemophilia A. Eur J Haematol. 1988;41 Suppl 4:334–40.
CAS
PubMed
Google Scholar
André S, Meslier Y, Dimitrov DJ, Repessé Y, Kaveri SV, Lacroix-Desmazes S, et al. A cellular viewpoint of anti-FVIII immune response in hemophilia A. Clin Rev Allergy Immunol. 2009;37 Suppl 2:105–13.
Article
PubMed
Google Scholar
Pautard B, D’Oiron R, Te Li Thiao V, Lavend’Homme R, Saint-Remy JM, Peerlinck K, et al. Successful immune tolerance induction by FVIII in hemophilia A patients with inhibitor may occur without deletion of FVIII-specific T cells. J Thromb Haemost. 2011;9 Suppl 6:1163–70.
Article
CAS
PubMed
Google Scholar
Qadura M, Othman M, Waters B, Chegeni R, Walker K, Labelle A, et al. Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemost. 2008;6 Suppl 12:2095–104.
Article
CAS
PubMed
Google Scholar
Rousset F, Garcia E, Defrance T, Péronne C, Vezzio N, Hsu DH, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A. 1992;89 Suppl 5:1890–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, et al. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol. 2000;1 Suppl 6:475–82.
Article
CAS
PubMed
Google Scholar
Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: A role in immune regulation? J Immunol. 2004;172 Suppl 6:3422–7.
Article
CAS
PubMed
Google Scholar
Lund FE. Cytokine-producing B lymphocytes - key regulators of immunity. Curr Opin Immunol. 2008;20 Suppl 3:332–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wojciechowski W, Harris DP, Sprague F, Mousseau B, Makris M, Kusser K, et al. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity. 2009;30 Suppl 3:421–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oldenburg J, Pavlova A. Genetic risk factors for inhibitors to factors VIII and IX. Haemophilia. 2006;12 Suppl 6:15–22.
Article
CAS
PubMed
Google Scholar
Lacroix-Desmazes S, Navarrete AM, André S, Bayry J, Kaveri SV, Dasgupta S. Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A. Blood. 2008;112 Suppl 2:240–9.
Article
CAS
PubMed
Google Scholar
Ghosh K, Shety S. Immune response to FVIII in hemophilia A: an overview of risk factors. Clin Rev Allergy Immunol. 2009;37 Suppl 2:58–66.
Article
CAS
PubMed
Google Scholar
Pinto P, Ghosh K, Shetty S. Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients. Haemophilia. 2012;18 Suppl 5:794–7.
Article
CAS
PubMed
Google Scholar