Overall proinflammatory and anti-inflammatory/regulatory cytokine patterns of lymphocytes. (a) Radar chart summarizes the percentage of proinflammatory and anti-inflammatory/regulatory cytokine balance in adaptive immune cells from BDs (light gray area), HAα-FVIII(−) patients (dark gray area), and HAα-FVIII(+) patients (black area). Each axis displays the proportion of each cytokine balance category within a given leukocyte subset. (b) Median percentage of each cytokine T cell population studied for groups BD, HAα-FVIII(−) and HAα-FVIII(+). Statistical significance at p < 0.05 is represented by letters “a”, “b”, and “c” for comparisons with BDs, HAα-FVIII(−) patients, and HAα-FVIII(+) patients, respectively.