Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, establ...
Authors: Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J. Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W. Snow, Charles R. Newton, David Roberts, Muhsin Aboud…
Anemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, ...
Authors: Ayenew Negesse, Temesgen Getaneh, Habtamu Temesgen, Tesfahun Taddege, Dube Jara and Zeleke Abebaw
Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes. There is no meta-analysis on anemia during pregnancy in ...
Authors: Ishag Adam, Yassin Ibrahim and Osama Elhardello
In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties o...
Authors: Enoch Aninagyei, Emmanuel Tetteh Doku, Patrick Adu, Alexander Egyir-Yawson and Desmond Omane Acheampong
An individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But ...
Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori i...
Authors: Sara Aljarad, Ahmad Alhamid, Ahmad Sankari Tarabishi, Ameen Suliman and Ziad Aljarad
Sickle cell disease (SCD) accounts for 5% of mortality in African children aged < 5 years. Improving the care management and quality of life of patients with SCD requires a reliable diagnosis in resource-limit...
Authors: Akueté Yvon Segbena, Aldiouma Guindo, Romain Buono, Irénée Kueviakoe, Dapa A. Diallo, Gregory Guernec, Mouhoudine Yerima, Pierre Guindo, Emilie Lauressergues, Aude Mondeilh, Valentina Picot and Valériane Leroy
Anemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(...
Authors: Benjamin Ahenkorah, Kwabena Nsiah, Peter Baffoe and Enoch Odame Anto
Sickle cell anaemia (SCA) is prevalent in sub-Saharan Africa, with high risk of complications requiring emergency care. There is limited information about presentation of patients with SCA to hospitals for eme...
Authors: Hendry R. Sawe, Teri A. Reynolds, Juma A. Mfinanga, Michael S. Runyon, Brittany L. Murray, Lee A. Wallis and Julie Makani
The use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among ot...
Authors: Zelalem Teklemariam, Habtamu Mitiku and Fitsum Weldegebreal
Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular ...
Authors: Olivier Mukuku, Joseph K. Sungu, Augustin Mulangu Mutombo, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama and Oscar Numbi Luboya
Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It is characterized by a series of metabolic manifestations...
Authors: Haileleul Micho, Yasin Mohammed, Daniel Hailu and Solomon Genet
Chromosomal abnormalities are diagnostic and prognostic key factors in acute myeloid leukemia (AML) patients, as they play a central role for risk stratification algorithms. High hyperdiploidy (HH), a rare cyt...
Authors: Abdulsamad Wafa, Suher ALmedania, Abdulmunim Aljapawe, Thomas Liehr, Soulaiman E. Soulaiman, Raja Mouna, Moneeb A. K. Othman and Walid ALachkar
Dengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. We sough...
In patients presenting with peripheral lymphadenopathy, it is critical to effectively identify those with underlying cancer who require urgent specialist care.
Authors: Andrea Kühnl, David Cunningham, Margaret Hutka, Clare Peckitt, Hamoun Rozati, Federica Morano, Irene Chong, Angela Gillbanks, Andrew Wotherspoon, Michelle Harris, Tracey Murray and Ian Chau
The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL).
Authors: Jean Uwingabiye, Hafid Zahid, Mohamed El Amrani, Fayçal Labrini, Abdelhak Elkhazraji, Driss El Kabbaj, Mohammed Benyahia, Anass Yahyaoui, Rachid Hadef and Nezha Messaoudi
Deficiency in coagulation factor VIII encoded by F8 results in the X-linked recessive bleeding disorder haemophilia A (HEMA). Here we describe the identification of a novel variant in the factor VIII gene, F8, in...
Authors: S. K. Nissen, A. L. Laursen, L. H. Poulsen and T. H. Mogensen
An insight into the utilization pattern helps in future planning of blood drive. This study was conducted to describe the demographic characteristics of the transfusion recipients and pattern of blood and bloo...
Authors: Henshaw Uchechi Okoroiwu and Ifeyinwa Maryann Okafor
In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its out...
Authors: Angesom Gebreweld, Delayehu Bekele and Aster Tsegaye
Anemia affects a significant part of the population in nearly every country in the globe. Iron requirements are greatest at ages 6–23 months when growth is extremely rapid and critically essential in critical ...
Authors: Bereket Geze Malako, Melese Sinaga Teshome and Tefera Belachew
In 1962 Victor Herbert developed megaloblastic anaemia four months after commencing a severely folate-deficient diet whereas, in his self-experiment 50 years later, this author took 19 months to fully deplete ...
Evidence-based guidelines for sickle cell disease (SCD) health maintenance and management have been developed for primary health care providers, but not for individuals with SCD. To improve the quality of care...
Authors: Robert Michael Cronin, Tilicia L. Mayo-Gamble, Sarah-Jo Stimpson, Sherif M. Badawy, Lori E. Crosby, Jeannie Byrd, Emmanuel J. Volanakis, Adetola A. Kassim, Jean L. Raphael, Velma M. Murry and Michael R. DeBaun
Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormaliti...
Authors: Bashir Abdrhman Bashir and Mohamed Salih Ali
Blood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red bloo...
Hematological abnormalities are common in HIV positive patients. Of these, thrombocytopenia is a known complication which has been associated with a variety of bleeding disorders. However, its magnitude and re...
Authors: Gashaw Garedew Woldeamanuel and Diresibachew Haile Wondimu
In individuals infected with HIV, hematological abnormalities are common and are associated with increased risk of disease progression and death. However, the profile of hematological abnormalities in HIV infe...
Authors: Tamirat Edie Fekene, Leja Hamza Juhar, Chernet Hailu Mengesha and Dawit Kibru Worku
Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the p...
Authors: Gashaw Garedew Woldeamanuel and Diresibachew Haile Wondimu
Immunophenotypic analysis of the bone marrow (BM) cells has proven to be helpful in the diagnosis of Myelodysplastic Syndromes (MDS). However, the usefulness of flow cytometry (FCM) for the detection of myelod...
Authors: Ana Aires, Maria dos Anjos Teixeira, Catarina Lau, Cláudia Moreira, Ana Spínola, Alexandra Mota, Inês Freitas, Jorge Coutinho and Margarida Lima
Sickle cell trait is usually an asymptomatic presentation of a patient with slightly different hemoglobin molecule makeup than normal. It is similar to a more serious disease, sickle cell disease, in which a p...
Myelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progressio...
5-Azacitidine administered as a 7-day dosing regimen (7–0-0) is approved in high risk IPSS myelodysplastic syndrome (MDS) patients. Alternative regimens such as a 5-day (5–0-0) or 7-day with a weekend break (5...
Authors: Roman M. Shapiro and Alejandro Lazo-Langner
Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to investigate the prevalence and clinical impact of factor V Leiden G1691A (FVL) and prothrombin G2...
Information on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother.
Authors: Berhanu Elfu Feleke and Teferi Elfu Feleke
Abnormal fibrinogens can be caused by clinically silent hereditary mutations. A new case was detected accidentally in an 11-year-old girl when routine pre-operative coagulation tests were performed for nasal t...
Authors: R. Marchi, M. Linares, H. Rojas, A. Ruiz-Sáez, M. Meyer, A. Casini and S.O. Brennan
Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological paramet...
Authors: Bamlaku Enawgaw, Nigist Adane, Betelihem Terefe, Fikir Asrie and Mulugeta Melku
Blood can save millions of lives. Even though people do not donate blood regularly, there is a constant effort to balance the supply and demand of blood. The aim of this study was, therefore, to determine the ...
Severe anaemia contributes significantly to mortality, especially in children under 5 years of age. Timely blood transfusion is known to improve outcomes. We investigated the magnitude of anaemia and emergency...
Authors: Catherine R. Shari, Hendry R. Sawe, Brittany L. Murray, Victor G. Mwafongo, Juma A. Mfinanga and Michael S. Runyon
It has been reported that patients with SCD do have an abnormal coagulation profile. Coagulopathy is thought to be one of the key factors that contribute to the vaso-occlusive crisis that characterises sickle ...
Authors: Shiekh Awoda, Ahmed A. Daak, Nazik Elmalaika Husain, Kebreab Ghebremeskel and Mustafa I. Elbashir
Anemia during pregnancy is one of the most common indirect obstetric cause of maternal mortality in developing countries. It is responsible for poor maternal and fetal outcomes. A limited number of studies wer...
Previously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate d...
Authors: Patrick Adu, Essel K. M. Bashirudeen, Florence Haruna, Edward Morkporkpor Adela and Richard K. D. Ephraim
In this study, we evaluate the association of different clinical profiles, laboratory and genetic biomarkers in patients with sickle cell anemia (SCA) and hemoglobin SC disease (HbSC) in attempt to characteriz...
Authors: Milena Magalhães Aleluia, Teresa Cristina Cardoso Fonseca, Regiana Quinto Souza, Fábia Idalina Neves, Caroline Conceição da Guarda, Rayra Pereira Santiago, Bruna Laís Almeida Cunha, Camylla Villas Boas Figueiredo, Sânzio Silva Santana, Silvana Sousa da Paz, Júnia Raquel Dutra Ferreira, Bruno Antônio Veloso Cerqueira and Marilda de Souza Gonçalves
Although a state of anemia is perceived to be associated with spaceflight, to date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not been performed during long-duration space mi...
Authors: Hawley Kunz, Heather Quiriarte, Richard J. Simpson, Robert Ploutz-Snyder, Kathleen McMonigal, Clarence Sams and Brian Crucian
There are a paucity of data on epistaxis as it pertains to sickle cell anaemia. Some case studies suggest epistaxis to be a significant complication in patients with sickle cell anaemia in sub-Saharan Africa; ...
Authors: Amina Nardo-Marino, Thomas N. Williams and Peter Olupot-Olupot
Anemia is a significant wide spread public health threat especially among the adolescent girls who are more vulnerable towards low level of hemoglobin particularly of low and middle income countries (LMICs). W...
Authors: Sabuj Kanti Mistry, Fatema Tuz Jhohura, Fouzia Khanam, Fahmida Akter, Safayet Khan, Fakir Md Yunus, Md Belal Hossain, Kaosar Afsana, Md Raisul Haque and Mahfuzar Rahman
Zinc protoporphyrin (ZPP) has been used to screen and manage iron deficiency in individual children, but it has also been recommended to assess population iron status. The diagnostic utility of ZPP used in com...
Authors: Emily M. Teshome, Andrew M. Prentice, Ayşe Y. Demir, Pauline E.A. Andang’o and Hans Verhoef
Despite the public health significance of anaemia in African children, its broader and often preventable risk factors remain largely under described. This study investigated, for the first time, the prevalence...
Authors: Ismail Dragon Legason, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot and John Banson Barugahare
Portal hypertension has a broad differential diagnosis. POEMS syndrome is an uncommon cause of it. POEMS syndrome is a rare disease involving multiple organs. In differential diagnosis of portal hypertension, ...
Circumcision in hemophiliacs is a delicate surgery because of bleeding risks that could be avoided by adequate substitution of coagulation factor. This practice is very challenging in countries where anti hemo...
Africa is the most affected continent with 200,000 new born affected by sickle cell anemia annually with of 5% of under five deaths. Nigeria has the largest sickle cell gene pool in the world with about 2% of ...
Authors: Olorunfemi Emmanuel Amoran, Ahmed Babatunde Jimoh, Omotola Ojo and Temitope Kuponiyi
Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of t...
Authors: Anne M. Andong, Eveline D. T. Ngouadjeu, Cavin E. Bekolo, Vincent S. Verla, Daniel Nebongo, Yannick Mboue-Djieka and Simeon-Pierre Choukem
