Hirano T, Akira S, Taga T, Kishimoto T: Biological and clinical aspects of interleukin 6. Immunol Today. 1990, 11: 443-449.
Article
CAS
PubMed
Google Scholar
Horii Y, Muraguchi A, Iwano M, Matsuda T, Hirayama T, Yamada H, Fujii Y, Dohi K, Ishikawa H, Ohmoto Y, Yoshizaki K, Hirano T, Kishimoto T: Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol. 1989, 15: 3949-3955.
Google Scholar
Raj DS: Role of interleukin-6 in the anemia of chronic disease. Semin Arthritis Rheum. 2009, 38: 382-388. 10.1016/j.semarthrit.2008.01.006.
Article
CAS
PubMed
Google Scholar
Kishimoto T, Akira S, Taga T: Interleukin-6 and its receptor: a paradigm for cytokines. Science. 1992, 258: 593-597. 10.1126/science.1411569.
Article
CAS
PubMed
Google Scholar
Nishimoto N, Kishimoto T, Yoshizaki K: Anti-interleukin 6 receptor antibody treatment in rheumatic disease. Ann Rheum Dis. 2000, 59 (Suppl 1): i21-i127.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krause A, Neitz S, Mägert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K: LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000, 480: 147-150. 10.1016/S0014-5793(00)01920-7.
Article
CAS
PubMed
Google Scholar
Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001, 276: 7806-7810. 10.1074/jbc.M008922200.
Article
CAS
PubMed
Google Scholar
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001, 276: 7811-7819. 10.1074/jbc.M008923200.
Article
CAS
PubMed
Google Scholar
Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 2001, 98: 8780-8785. 10.1073/pnas.151179498.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganz T, Nemeth E: Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011, 62: 347-360. 10.1146/annurev-med-050109-142444.
Article
CAS
PubMed
Google Scholar
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004, 113: 1271-1276. 10.1172/JCI200420945.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003, 101: 2461-2463. 10.1182/blood-2002-10-3235.
Article
CAS
PubMed
Google Scholar
Nieken J, Mulder NH, Buter J, Vellenga E, Limburg PC, Piers DA, de Vries EG: Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients. Blood. 1995, 86: 900-905.
CAS
PubMed
Google Scholar
Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D: Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005, 106: 1864-1866. 10.1182/blood-2005-03-1159.
Article
CAS
PubMed
Google Scholar
Caliskan Y, Yelken B, Ozkok A, Gorgulu N, Yazici H, Telci A, Yildiz A: Lower serum prohepcidin levels associated with lower iron and erythropoietin requirements in hemodialysis patients with chronic hepatitis C. BMC Nephrol. 2012, 13: 56-10.1186/1471-2369-13-56. doi:10.1186/1471-2369-13-56
Article
CAS
PubMed
PubMed Central
Google Scholar
Kuo HC, Yang YL, Chuang JH, Tiao MM, Yu HR, Huang LT, Yang KD, Chang WC, Lee CP, Huang YH: Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in Kawasaki disease. J Clin Immunol. 2012, 32: 746-752. 10.1007/s10875-012-9668-1.
Article
CAS
PubMed
Google Scholar
Maruna P, Vokurka M, Lindner J: Plasma hepcidin correlates positively with interleukin-6 in patients undergoing pulmonary endarterectomy. Physiol Res. 2011, 60: 493-502.
CAS
PubMed
Google Scholar
Robson-Ansley P, Walshe I, Ward D: The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise. Cytokine. 2011, 53: 196-200. 10.1016/j.cyto.2010.10.001.
Article
CAS
PubMed
Google Scholar
Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA: Hepcidin is a key mediator of anemia of inflammation in Crohn’s disease. J Crohns Colitis. 2013, 7: e286-e291. 10.1016/j.crohns.2012.10.013.
Article
PubMed
Google Scholar
Ganz T: Hepcidin and iron regulation, 10 years later. Blood. 2011, 117: 4425-4433. 10.1182/blood-2011-01-258467.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganz T: Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003, 102: 783-788. 10.1182/blood-2003-03-0672.
Article
CAS
PubMed
Google Scholar
Falkensammer CE, Thurnher M, Leonhartsberger N, Ramoner R: C-reactive protein is a strong predictor for anaemia in renal cell carcinoma: role of IL-6 in overall survival. BJU Int. 2011, 107: 1893-1898. 10.1111/j.1464-410X.2010.09817.x.
Article
CAS
PubMed
Google Scholar
Eleftheriadis T, Pissas G, Remoundou M, Filippidis G, Antoniadi G, Oustampasidou N, Liakopoulos V, Stefanidis I: Ferroportin in monocytes of hemodialysis patients and its associations with hepcidin, inflammation, markers of iron status and resistance to erythropoietin. Int Urol Nephrol. 2013, [Epub ahead of print]
Google Scholar
Eguchi A, Mochizuki T, Tsukada M, Kataoka K, Hamaguchi Y, Oguni S, Nitta K, Tsuchiya K: Serum hepcidin levels and reticulocyte hemoglobin concentrations as indicators of the iron status of peritoneal dialysis patients. Int J Nephrol. 2012, 2012: 239476-doi:10.1155/2012/239476. Epub 2012 Nov 1
Article
PubMed
PubMed Central
Google Scholar
Schwarz P, Kübler JA, Strnad P, Müller K, Barth TF, Gerloff A, Feick P, Peyssonnaux C, Vaulont S, Adler G, Kulaksiz H: Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Gut. 2012, 61: 193-201. 10.1136/gut.2011.241208.
Article
CAS
PubMed
Google Scholar
Lee SY, Song EY, Yun YM, Yoon SY, Cho YH, Kim SY, Lee MH: Serum prohepcidin levels in Helicobacter pylori infected patients with iron deficiency anemia. Korean J Intern Med. 2010, 25: 195-200. 10.3904/kjim.2010.25.2.195.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP: An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS One. 2008, 3: e4030-10.1371/journal.pone.0004030.
Article
PubMed
PubMed Central
Google Scholar
Nakagawa H, Tamura T, Mitsuda Y, Kurata M, Goto Y, Kamiya Y, Kondo T, Hamajima N: Association between Helicobacter pylori infection detected by the 13C-urea breath test and low serum ferritin levels among Japanese adults. Helicobacter. 2013, 18: 309-315. 10.1111/hel.12044.
Article
CAS
PubMed
Google Scholar
Ganz T, Nemeth E: Hepcidin and iron homeostasis. Biochim Biophys Acta. 1823, 2012: 1434-1443.
Google Scholar
Wiltink WF, Kruithof J, Mol C, Bos MG, van Eijk HG: Diurnal and nocturnal variations of the serum iron in normal subjects. Clin Chim Acta. 1973, 49: 99-104. 10.1016/0009-8981(73)90348-3.
Article
CAS
PubMed
Google Scholar
Sinniah R, Doggart JR, Neill DW: Diurnal variations of the serum iron in normal subjects and in patients with haemochromatosis. Br J Haematol. 1969, 17: 351-358. 10.1111/j.1365-2141.1969.tb01381.x.
Article
CAS
PubMed
Google Scholar
Troutt JS, Rudling M, Persson L, Ståhle L, Angelin B, Butterfield AM, Schade AE, Cao G, Konrad RJ: Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration. Clin Chem. 2012, 58: 1225-1232. 10.1373/clinchem.2012.186866.
Article
CAS
PubMed
Google Scholar
Mortensen RF: C-reactive protein, inflammation, and innate immunity. Immunol Res. 2001, 24: 163-176. 10.1385/IR:24:2:163.
Article
CAS
PubMed
Google Scholar