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Non-malignant hematological diseases

The non-malignant hematological diseases sections covers all aspects of non-malignant hematological diseases including basic research and therapies/clinical management of these conditions

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  1. Content type: Research article

    Blood can only be given from generous donors. The main objective of this study was to assess the knowledge, attitude and practice (KAP) and associated factors of blood donation among health care workers in Wol...

    Authors: Dawit Malako, Fissehatsion Yoseph and Mebratu Legesse Bekele

    Citation: BMC Hematology 2019 19:10

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  2. Content type: Research article

    Sickle cell disease (SCD) is a chronic hematologic disease associated with increased morbidity and mortality. Hemoglobinopathies are the most prevalent genetic disease globally, and SCD is estimated to affect ...

    Authors: David Muthahi Kambasu, Joseph Rujumba, Hervé Monka Lekuya, Deogratias Munube and Ezekiel Mupere

    Citation: BMC Hematology 2019 19:9

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  3. Content type: Research article

    Anemia, defined as a low blood hemoglobin concentration, has been shown to be a major public health concern in low-income countries like Ethiopia. School-age children are the most vulnerable population groups ...

    Authors: Eshetu Zerihun Tariku, Getaneh Alemu Abebe, Zeleke Aschalew Melketsedik, Befikadu Tariku Gutema, Nega Degefa Megersa, Muluken Bekele Sorrie, Feleke Gebremeskel Weldehawariat and Eskeziyaw Agedew Getahun

    Citation: BMC Hematology 2019 19:6

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  4. Content type: Research article

    Transfusion-transmissible infections pose a major health risk in developing countries, including Eritrea. In the present study, we sought to determine the prevalence of specific transfusion transmitted infecti...

    Authors: Yacob Tesfamichael Keleta, Oliver Okoth Achila, Absera Woldu Haile, Bereket Habteslasie Gebrecherkos, Danait Tareke Tesfaldet, Kibrom Solomon Teklu, Mesuda Abrhum Mohammed and Selihom Tesfaslase Ghedel

    Citation: BMC Hematology 2019 19:5

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  5. Content type: Research article

    Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency...

    Authors: Absra Solomon, Mintewab Hussein, Mikias Negash, Abdurezak Ahmed, Fitsum Bekele and Daniel Kahase

    Citation: BMC Hematology 2019 19:2

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  6. Content type: Research article

    Early detection and treatment of iron deficiency during pregnancy is crucial for optimum pregnancy outcomes. Anaemia is a late indictor of iron deficiency measured as Hb < 11 g/dL, and is widely used as a prox...

    Authors: Miruna Sudharshani Kalaimani Rabindrakumar, V. Pujitha Wickramasinghe, Lallindra Gooneratne, Carukshi Arambepola, Hemantha Senanayake and Tharanga Thoradeniya

    Citation: BMC Hematology 2018 18:37

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  7. Content type: Research article

    Blood transfusion is an essential component of the health care system of every country and patients who require blood transfusion service as part of the clinical management of their condition have the right to...

    Authors: Shamsudeen Mohammed and Harry Barton Essel

    Citation: BMC Hematology 2018 18:36

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  8. Content type: Research article

    Infection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infection...

    Authors: Rapee Lertpongpiroon, Ekarat Rattarittamrong, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Adisak Tantiworawit, Parichat Salee and Lalita Norasetthada

    Citation: BMC Hematology 2018 18:35

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  9. Content type: Research article

    Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, establ...

    Authors: Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J. Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W. Snow, Charles R. Newton, David Roberts, Muhsin Aboud…

    Citation: BMC Hematology 2018 18:33

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  10. Content type: Research article

    Anemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, ...

    Authors: Ayenew Negesse, Temesgen Getaneh, Habtamu Temesgen, Tesfahun Taddege, Dube Jara and Zeleke Abebaw

    Citation: BMC Hematology 2018 18:32

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  11. Content type: Research article

    Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes. There is no meta-analysis on anemia during pregnancy in ...

    Authors: Ishag Adam, Yassin Ibrahim and Osama Elhardello

    Citation: BMC Hematology 2018 18:31

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  12. Content type: Research article

    An individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But ...

    Authors: Tadele Mulaw, Amare Tariku, Adino Tesfahun Tsegaye and Zegeye Abebe

    Citation: BMC Hematology 2018 18:29

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  13. Content type: Research article

    Anemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(...

    Authors: Benjamin Ahenkorah, Kwabena Nsiah, Peter Baffoe and Enoch Odame Anto

    Citation: BMC Hematology 2018 18:27

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  14. Content type: Research article

    Sickle cell disease (SCD) accounts for 5% of mortality in African children aged < 5 years. Improving the care management and quality of life of patients with SCD requires a reliable diagnosis in resource-limit...

    Authors: Akueté Yvon Segbena, Aldiouma Guindo, Romain Buono, Irénée Kueviakoe, Dapa A. Diallo, Gregory Guernec, Mouhoudine Yerima, Pierre Guindo, Emilie Lauressergues, Aude Mondeilh, Valentina Picot and Valériane Leroy

    Citation: BMC Hematology 2018 18:26

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  15. Content type: Research article

    Sickle cell anaemia (SCA) is prevalent in sub-Saharan Africa, with high risk of complications requiring emergency care. There is limited information about presentation of patients with SCA to hospitals for eme...

    Authors: Hendry R. Sawe, Teri A. Reynolds, Juma A. Mfinanga, Michael S. Runyon, Brittany L. Murray, Lee A. Wallis and Julie Makani

    Citation: BMC Hematology 2018 18:25

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  16. Content type: Research article

    The use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among ot...

    Authors: Zelalem Teklemariam, Habtamu Mitiku and Fitsum Weldegebreal

    Citation: BMC Hematology 2018 18:24

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  17. Content type: Research article

    Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular ...

    Authors: Olivier Mukuku, Joseph K. Sungu, Augustin Mulangu Mutombo, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama and Oscar Numbi Luboya

    Citation: BMC Hematology 2018 18:23

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  18. Content type: Research article

    Dengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. We sough...

    Authors: Juthatip Chaloemwong, Adisak Tantiworawit, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong and Lalita Norasetthada

    Citation: BMC Hematology 2018 18:20

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  19. Content type: Research article

    An insight into the utilization pattern helps in future planning of blood drive. This study was conducted to describe the demographic characteristics of the transfusion recipients and pattern of blood and bloo...

    Authors: Henshaw Uchechi Okoroiwu and Ifeyinwa Maryann Okafor

    Citation: BMC Hematology 2018 18:16

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  20. Content type: Research article

    In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its out...

    Authors: Angesom Gebreweld, Delayehu Bekele and Aster Tsegaye

    Citation: BMC Hematology 2018 18:15

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  21. Content type: Research article

    Anemia affects a significant part of the population in nearly every country in the globe. Iron requirements are greatest at ages 6–23 months when growth is extremely rapid and critically essential in critical ...

    Authors: Bereket Geze Malako, Melese Sinaga Teshome and Tefera Belachew

    Citation: BMC Hematology 2018 18:14

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  22. Content type: Research article

    Evidence-based guidelines for sickle cell disease (SCD) health maintenance and management have been developed for primary health care providers, but not for individuals with SCD. To improve the quality of care...

    Authors: Robert Michael Cronin, Tilicia L. Mayo-Gamble, Sarah-Jo Stimpson, Sherif M. Badawy, Lori E. Crosby, Jeannie Byrd, Emmanuel J. Volanakis, Adetola A. Kassim, Jean L. Raphael, Velma M. Murry and Michael R. DeBaun

    Citation: BMC Hematology 2018 18:12

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  23. Content type: Research article

    Hematological abnormalities are common in HIV positive patients. Of these, thrombocytopenia is a known complication which has been associated with a variety of bleeding disorders. However, its magnitude and re...

    Authors: Gashaw Garedew Woldeamanuel and Diresibachew Haile Wondimu

    Citation: BMC Hematology 2018 18:9

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  24. Content type: Research article

    In individuals infected with HIV, hematological abnormalities are common and are associated with increased risk of disease progression and death. However, the profile of hematological abnormalities in HIV infe...

    Authors: Tamirat Edie Fekene, Leja Hamza Juhar, Chernet Hailu Mengesha and Dawit Kibru Worku

    Citation: BMC Hematology 2018 18:8

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  25. Content type: Research article

    Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the p...

    Authors: Gashaw Garedew Woldeamanuel and Diresibachew Haile Wondimu

    Citation: BMC Hematology 2018 18:7

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  26. Content type: Research article

    Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological paramet...

    Authors: Bamlaku Enawgaw, Nigist Adane, Betelihem Terefe, Fikir Asrie and Mulugeta Melku

    Citation: BMC Hematology 2017 17:21

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  27. Content type: Research article

    Anemia during pregnancy is one of the most common indirect obstetric cause of maternal mortality in developing countries. It is responsible for poor maternal and fetal outcomes. A limited number of studies wer...

    Authors: Getachew Mullu Kassa, Achenef Asmamaw Muche, Abadi Kidanemariam Berhe and Gedefaw Abeje Fekadu

    Citation: BMC Hematology 2017 17:17

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  28. Content type: Research article

    Previously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate d...

    Authors: Patrick Adu, Essel K. M. Bashirudeen, Florence Haruna, Edward Morkporkpor Adela and Richard K. D. Ephraim

    Citation: BMC Hematology 2017 17:16

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  29. Content type: Research article

    In this study, we evaluate the association of different clinical profiles, laboratory and genetic biomarkers in patients with sickle cell anemia (SCA) and hemoglobin SC disease (HbSC) in attempt to characteriz...

    Authors: Milena Magalhães Aleluia, Teresa Cristina Cardoso Fonseca, Regiana Quinto Souza, Fábia Idalina Neves, Caroline Conceição da Guarda, Rayra Pereira Santiago, Bruna Laís Almeida Cunha, Camylla Villas Boas Figueiredo, Sânzio Silva Santana, Silvana Sousa da Paz, Júnia Raquel Dutra Ferreira, Bruno Antônio Veloso Cerqueira and Marilda de Souza Gonçalves

    Citation: BMC Hematology 2017 17:15

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  30. Content type: Research article

    Although a state of anemia is perceived to be associated with spaceflight, to date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not been performed during long-duration space mi...

    Authors: Hawley Kunz, Heather Quiriarte, Richard J. Simpson, Robert Ploutz-Snyder, Kathleen McMonigal, Clarence Sams and Brian Crucian

    Citation: BMC Hematology 2017 17:12

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  31. Content type: Research article

    There are a paucity of data on epistaxis as it pertains to sickle cell anaemia. Some case studies suggest epistaxis to be a significant complication in patients with sickle cell anaemia in sub-Saharan Africa; ...

    Authors: Amina Nardo-Marino, Thomas N. Williams and Peter Olupot-Olupot

    Citation: BMC Hematology 2017 17:14

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  32. Content type: Research article

    Anemia is a significant wide spread public health threat especially among the adolescent girls who are more vulnerable towards low level of hemoglobin particularly of low and middle income countries (LMICs). W...

    Authors: Sabuj Kanti Mistry, Fatema Tuz Jhohura, Fouzia Khanam, Fahmida Akter, Safayet Khan, Fakir Md Yunus, Md Belal Hossain, Kaosar Afsana, Md Raisul Haque and Mahfuzar Rahman

    Citation: BMC Hematology 2017 17:13

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  33. Content type: Research article

    Despite the public health significance of anaemia in African children, its broader and often preventable risk factors remain largely under described. This study investigated, for the first time, the prevalence...

    Authors: Ismail Dragon Legason, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot and John Banson Barugahare

    Citation: BMC Hematology 2017 17:10

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  34. Content type: Research article

    Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of t...

    Authors: Anne M. Andong, Eveline D. T. Ngouadjeu, Cavin E. Bekolo, Vincent S. Verla, Daniel Nebongo, Yannick Mboue-Djieka and Simeon-Pierre Choukem

    Citation: BMC Hematology 2017 17:7

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  35. Content type: Research article

    Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leu...

    Authors: Tsion Sahle, Tilahun Yemane and Lealem Gedefaw

    Citation: BMC Hematology 2017 17:2

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  36. Content type: Research article

    Anemia is a strong predictor of mortality and poor quality of life among persons with either renal impairment or HIV infection. In this study, we investigated the prevalence of anemia and its association with ...

    Authors: Temesgen Fiseha, Zemenu Tamir, Abdurahaman Seid and Wondmagegn Demsiss

    Citation: BMC Hematology 2017 17:1

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  37. Content type: Research article

    In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate ...

    Authors: Muriel N. Maeder, Henintsoa M. Rabezanahary, Norosoa J. Zafindraibe, Martin Raoelina Randriatiana, Tahinamandranto Rasamoelina, Andry T. Rakotoarivo, Philippe Vanhems, Jonathan Hoffmann, Thomas Bénet, Mala Rakoto Andrianarivelo and Olivat A. Rakoto-Alson

    Citation: BMC Hematology 2016 16:30

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  38. Content type: Research article

    Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in...

    Authors: Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi and Tahir Shamsi

    Citation: BMC Hematology 2016 16:27

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  39. Content type: Research article

    Although the demand for blood supply has progressively increased in developing countries, evidences indicate that there is a major shortage of blood and blood products in these countries, particularly in Ethio...

    Authors: Yenework Acham Jemberu, Ahmed Esmael and Kedir Y. Ahmed

    Citation: BMC Hematology 2016 16:23

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  40. Content type: Study protocol

    Sickle cell disease (SCD) is endemic in non-Western countries. Due to migration, the prevalence of SCD in the Netherlands has increased. Adherence to medical treatment is recognized as a major problem area. Th...

    Authors: Marlous J. Madderom, Jessica Heijdra, Elisabeth M. W. J. Utens, Suzanne Polinder, Anita W. Rijneveld and Marjon H. Cnossen

    Citation: BMC Hematology 2016 16:21

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  41. Content type: Research article

    Iron deficiency anemia is highly prevalent in patients with chronic kidney disease and is often treated with intravenous iron. There are few trials directly comparing the safety and efficacy of different intra...

    Authors: William E. Strauss, Naomi V. Dahl, Zhu Li, Gloria Lau and Lee F. Allen

    Citation: BMC Hematology 2016 16:20

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  42. Content type: Research article

    A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the...

    Authors: Srdjan Denic, Hassib Narchi, Lolowa A. Al Mekaini, Suleiman Al-Hammadi, Omar N. Al Jabri and Abdul-Kader Souid

    Citation: BMC Hematology 2016 16:15

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  43. Content type: Research article

    Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies c...

    Authors: Martha L. Louzada, Cyrus C. Hsia, Fatimah Al-Ani, Fiona Ralley, Anargyros Xenocostas, Janet Martin, Sarah E. Connelly, Ian H. Chin-Yee, Leonard Minuk and Alejandro Lazo-Langner

    Citation: BMC Hematology 2016 16:7

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