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  1. Abnormal fibrinogens can be caused by clinically silent hereditary mutations. A new case was detected accidentally in an 11-year-old girl when routine pre-operative coagulation tests were performed for nasal t...

    Authors: R. Marchi, M. Linares, H. Rojas, A. Ruiz-Sáez, M. Meyer, A. Casini and S.O. Brennan

    Citation: BMC Hematology 2017 17:22

    Content type: Research article

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  2. Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological paramet...

    Authors: Bamlaku Enawgaw, Nigist Adane, Betelihem Terefe, Fikir Asrie and Mulugeta Melku

    Citation: BMC Hematology 2017 17:21

    Content type: Research article

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  3. Blood can save millions of lives. Even though people do not donate blood regularly, there is a constant effort to balance the supply and demand of blood. The aim of this study was, therefore, to determine the ...

    Authors: Habtom Woldeab Gebresilase, Robera Olana Fite and Sileshi Garoma Abeya

    Citation: BMC Hematology 2017 17:20

    Content type: Research article

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  4. Severe anaemia contributes significantly to mortality, especially in children under 5 years of age. Timely blood transfusion is known to improve outcomes. We investigated the magnitude of anaemia and emergency...

    Authors: Catherine R. Shari, Hendry R. Sawe, Brittany L. Murray, Victor G. Mwafongo, Juma A. Mfinanga and Michael S. Runyon

    Citation: BMC Hematology 2017 17:19

    Content type: Research article

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  5. It has been reported that patients with SCD do have an abnormal coagulation profile. Coagulopathy is thought to be one of the key factors that contribute to the vaso-occlusive crisis that characterises sickle ...

    Authors: Shiekh Awoda, Ahmed A. Daak, Nazik Elmalaika Husain, Kebreab Ghebremeskel and Mustafa I. Elbashir

    Citation: BMC Hematology 2017 17:18

    Content type: Research article

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  6. Anemia during pregnancy is one of the most common indirect obstetric cause of maternal mortality in developing countries. It is responsible for poor maternal and fetal outcomes. A limited number of studies wer...

    Authors: Getachew Mullu Kassa, Achenef Asmamaw Muche, Abadi Kidanemariam Berhe and Gedefaw Abeje Fekadu

    Citation: BMC Hematology 2017 17:17

    Content type: Research article

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  7. Previously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate d...

    Authors: Patrick Adu, Essel K. M. Bashirudeen, Florence Haruna, Edward Morkporkpor Adela and Richard K. D. Ephraim

    Citation: BMC Hematology 2017 17:16

    Content type: Research article

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  8. In this study, we evaluate the association of different clinical profiles, laboratory and genetic biomarkers in patients with sickle cell anemia (SCA) and hemoglobin SC disease (HbSC) in attempt to characteriz...

    Authors: Milena Magalhães Aleluia, Teresa Cristina Cardoso Fonseca, Regiana Quinto Souza, Fábia Idalina Neves, Caroline Conceição da Guarda, Rayra Pereira Santiago, Bruna Laís Almeida Cunha, Camylla Villas Boas Figueiredo, Sânzio Silva Santana, Silvana Sousa da Paz, Júnia Raquel Dutra Ferreira, Bruno Antônio Veloso Cerqueira and Marilda de Souza Gonçalves

    Citation: BMC Hematology 2017 17:15

    Content type: Research article

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  9. Although a state of anemia is perceived to be associated with spaceflight, to date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not been performed during long-duration space mi...

    Authors: Hawley Kunz, Heather Quiriarte, Richard J. Simpson, Robert Ploutz-Snyder, Kathleen McMonigal, Clarence Sams and Brian Crucian

    Citation: BMC Hematology 2017 17:12

    Content type: Research article

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  10. There are a paucity of data on epistaxis as it pertains to sickle cell anaemia. Some case studies suggest epistaxis to be a significant complication in patients with sickle cell anaemia in sub-Saharan Africa; ...

    Authors: Amina Nardo-Marino, Thomas N. Williams and Peter Olupot-Olupot

    Citation: BMC Hematology 2017 17:14

    Content type: Research article

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  11. Anemia is a significant wide spread public health threat especially among the adolescent girls who are more vulnerable towards low level of hemoglobin particularly of low and middle income countries (LMICs). W...

    Authors: Sabuj Kanti Mistry, Fatema Tuz Jhohura, Fouzia Khanam, Fahmida Akter, Safayet Khan, Fakir Md Yunus, Md Belal Hossain, Kaosar Afsana, Md Raisul Haque and Mahfuzar Rahman

    Citation: BMC Hematology 2017 17:13

    Content type: Research article

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  12. Zinc protoporphyrin (ZPP) has been used to screen and manage iron deficiency in individual children, but it has also been recommended to assess population iron status. The diagnostic utility of ZPP used in com...

    Authors: Emily M. Teshome, Andrew M. Prentice, Ayşe Y. Demir, Pauline E.A. Andang’o and Hans Verhoef

    Citation: BMC Hematology 2017 17:11

    Content type: Research article

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  13. Despite the public health significance of anaemia in African children, its broader and often preventable risk factors remain largely under described. This study investigated, for the first time, the prevalence...

    Authors: Ismail Dragon Legason, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot and John Banson Barugahare

    Citation: BMC Hematology 2017 17:10

    Content type: Research article

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  14. Circumcision in hemophiliacs is a delicate surgery because of bleeding risks that could be avoided by adequate substitution of coagulation factor. This practice is very challenging in countries where anti hemo...

    Authors: Moussa Seck, Aloïse Sagna, Mame Sokhna Guéye, Blaise Félix Faye, Diariétou Sy, Sokhna Aissatou Touré, Abibatou Sall, Awa Oumar Touré and Saliou Diop

    Citation: BMC Hematology 2017 17:8

    Content type: Research article

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  15. Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of t...

    Authors: Anne M. Andong, Eveline D. T. Ngouadjeu, Cavin E. Bekolo, Vincent S. Verla, Daniel Nebongo, Yannick Mboue-Djieka and Simeon-Pierre Choukem

    Citation: BMC Hematology 2017 17:7

    Content type: Research article

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  16. Africa is the most affected continent with 200,000 new born affected by sickle cell anemia annually with of 5% of under five deaths. Nigeria has the largest sickle cell gene pool in the world with about 2% of ...

    Authors: Olorunfemi Emmanuel Amoran, Ahmed Babatunde Jimoh, Omotola Ojo and Temitope Kuponiyi

    Citation: BMC Hematology 2017 17:6

    Content type: Research article

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  17. Familial and acquired thrombophilia are often etiologic for idiopathic hip and jaw osteonecrosis (ON), and testosterone therapy (TT) can interact with thrombophilia, worsening ON.

    Authors: Michael Ian Jarman, Kevin Lee, Ariel Kanevsky, Sarah Min, Ilana Schlam, Chris Mahida, Ali Huda, Alexander Milgrom, Naila Goldenberg, Charles J. Glueck and Ping Wang

    Citation: BMC Hematology 2017 17:5

    Content type: Case report

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  18. Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammatio...

    Authors: Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang and Amal M. Saeed

    Citation: BMC Hematology 2017 17:4

    Content type: Research article

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  19. Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Curren...

    Authors: Cristhiam M. Rojas-Hernandez, Jacklyn Nemunaitis, Kristopher D. Marjon, Daniel Bustamante, Qian-Yun Zhang and Jennifer M. Gillette

    Citation: BMC Hematology 2017 17:3

    Content type: Case report

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  20. Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leu...

    Authors: Tsion Sahle, Tilahun Yemane and Lealem Gedefaw

    Citation: BMC Hematology 2017 17:2

    Content type: Research article

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  21. Anemia is a strong predictor of mortality and poor quality of life among persons with either renal impairment or HIV infection. In this study, we investigated the prevalence of anemia and its association with ...

    Authors: Temesgen Fiseha, Zemenu Tamir, Abdurahaman Seid and Wondmagegn Demsiss

    Citation: BMC Hematology 2017 17:1

    Content type: Research article

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  22. In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate ...

    Authors: Muriel N. Maeder, Henintsoa M. Rabezanahary, Norosoa J. Zafindraibe, Martin Raoelina Randriatiana, Tahinamandranto Rasamoelina, Andry T. Rakotoarivo, Philippe Vanhems, Jonathan Hoffmann, Thomas Bénet, Mala Rakoto Andrianarivelo and Olivat A. Rakoto-Alson

    Citation: BMC Hematology 2016 16:30

    Content type: Research article

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  23. Hemophagocytic lymphohistiocytosis in adults is often secundary to an infection or a neoplasm. In this last case, T cell lymphomas are the most frequent causes. Hemophagocytic lymphohistiocytosis secundary to ...

    Authors: El Mehdi Mahtat, Maryem Zine, Mohamed Allaoui, Malika Kerbout, Nezha Messaoudi, Kamal Doghmi and Mohamed Mikdame

    Citation: BMC Hematology 2016 16:28

    Content type: Case report

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  24. Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in...

    Authors: Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi and Tahir Shamsi

    Citation: BMC Hematology 2016 16:27

    Content type: Research article

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  25. When availability and/or affordability of anti-hemophilic factor concentrates are limited, optimal prophylaxis regimens in severe hemophilia A (HA) remain to be determined. In selected situations, low-dose dai...

    Authors: Terry Mizrahi, Jean St-Louis, Nancy L. Young, Francine Ménard, Nichan Zourikian, Evemie Dubé and Georges E. Rivard

    Citation: BMC Hematology 2016 16:26

    Content type: Research article

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  26. Since the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However,...

    Authors: Daniele Kazue Sugioka, Carlos Eduardo Ibaldo Gonçalves and Maria da Graça Bicalho

    Citation: BMC Hematology 2016 16:25

    Content type: Research article

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  27. Although the demand for blood supply has progressively increased in developing countries, evidences indicate that there is a major shortage of blood and blood products in these countries, particularly in Ethio...

    Authors: Yenework Acham Jemberu, Ahmed Esmael and Kedir Y. Ahmed

    Citation: BMC Hematology 2016 16:23

    Content type: Research article

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  28. Anticoagulant therapy is prescribed for millions of patients worldwide for the prevention and treatment of both arterial and venous thrombosis. Historically, only vitamin K antagonists have been available for ...

    Authors: Vivian Auyeung, Jignesh P. Patel, John K. Abdou, Bipin Vadher, Lynda Bonner, Alison Brown, Lara N. Roberts, Raj K. Patel and Roopen Arya

    Citation: BMC Hematology 2016 16:22

    Content type: Study protocol

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  29. Sickle cell disease (SCD) is endemic in non-Western countries. Due to migration, the prevalence of SCD in the Netherlands has increased. Adherence to medical treatment is recognized as a major problem area. Th...

    Authors: Marlous J. Madderom, Jessica Heijdra, Elisabeth M. W. J. Utens, Suzanne Polinder, Anita W. Rijneveld and Marjon H. Cnossen

    Citation: BMC Hematology 2016 16:21

    Content type: Study protocol

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  30. Iron deficiency anemia is highly prevalent in patients with chronic kidney disease and is often treated with intravenous iron. There are few trials directly comparing the safety and efficacy of different intra...

    Authors: William E. Strauss, Naomi V. Dahl, Zhu Li, Gloria Lau and Lee F. Allen

    Citation: BMC Hematology 2016 16:20

    Content type: Research article

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  31. Bone marrow examination may be required to discriminate causes of thrombocytopenia as hypoproductive or hyperdestructive. However, this procedure is invasive and time consuming. This study assessed the diagnos...

    Authors: Mikias Negash, Aster Tsegaye and Amha G/Medhin

    Citation: BMC Hematology 2016 16:18

    Content type: Research article

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  32. Survival analysis is commonly used to determine the treatment effect among acute lymphoblastic leukemia (ALL) patients who undergo allogeneic stem cell transplantation (allo-SCT) or other treatments. The aim o...

    Authors: Chatree Chai-Adisaksopha, Alfonso Iorio, Christopher Hillis, Wendy Lim and Mark Crowther

    Citation: BMC Hematology 2016 16:17

    Content type: Research article

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  33. Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and...

    Authors: C Sekaggya, D Nalwanga, A Von Braun, R Nakijoba, A Kambugu, J Fehr, M Lamorde and B Castelnuovo

    Citation: BMC Hematology 2016 16:16

    Content type: Research article

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  34. A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the...

    Authors: Srdjan Denic, Hassib Narchi, Lolowa A. Al Mekaini, Suleiman Al-Hammadi, Omar N. Al Jabri and Abdul-Kader Souid

    Citation: BMC Hematology 2016 16:15

    Content type: Research article

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  35. Multiple myeloma is a plasma cell tumour with an annual incidence in the UK of approximately 40–50 per million i.e. about 4500 new cases per annum. The triple combination cyclophosphamide, bortezomib (Velcade®...

    Authors: Sarah Brown, Samantha Hinsley, Mónica Ballesteros, Sue Bourne, Paul McGarry, Debbie Sherratt, Louise Flanagan, Walter Gregory, Jamie Cavenagh, Roger Owen, Cathy Williams, Martin Kaiser, Eric Low and Kwee Yong

    Citation: BMC Hematology 2016 16:14

    Content type: Study protocol

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  36. This study was undertaken to explore the longitudinal patterns of health-related quality of life (HRQoL) among youth and young adults with Hemophilia A (HA) over a 3-year period. This report presents the basel...

    Authors: J. St-Louis, D. J. Urajnik, F. Ménard, S. Cloutier, R. J. Klaassen, B. Ritchie, G. E. Rivard, M. Warner, V. Blanchette and N. L. Young

    Citation: BMC Hematology 2016 16:13

    Content type: Research article

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  37. CC-486 is an oral formulation of the epigenetic modifier azacitidine. In an expanded phase 1 trial, CC-486 demonstrated clinical and biological activity in patients with International Prognostic Scoring System...

    Authors: Guillermo Garcia-Manero, Antonio Almeida, Aristoteles Giagounidis, Uwe Platzbecker, Regina Garcia, Maria Teresa Voso, Stephen R. Larsen, David Valcarcel, Lewis R. Silverman, Barry Skikne and Valeria Santini

    Citation: BMC Hematology 2016 16:12

    Content type: Study protocol

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  38. Langerhans cells (LC) are bone marrow-derived cells in the skin. The LC donor/recipient chimerism is assumed to influence the incidence and severity of graft-versus-host disease (GVHD) after hematopoietic stem...

    Authors: Sabrina Peters, Christian Junghanss, Anne Knueppel, Hugo Murua Escobar, Catrin Roolf, Gudrun Knuebel, Anett Sekora, Iris Lindner, Ludwig Jonas, Mathias Freund and Sandra Lange

    Citation: BMC Hematology 2016 16:11

    Content type: Research article

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  39. Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL is the most common type of leukemia in Western populatio...

    Authors: Abibatou Sall, Awa Oumar Touré, Fatimata Bintou Sall, Moussa Ndour, Seynabou Fall, Abdoulaye Sène, Blaise Félix Faye, Moussa Seck, Macoura Gadji, Tandakha Ndiaye Dièye, Claire Mathiot, Sophie Reynaud, Saliou Diop and Martine Raphaël

    Citation: BMC Hematology 2016 16:10

    Content type: Research article

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  40. Fibrin provides a temporary matrix at the site of vascular injury. The aims of the present work were (1) to follow fibrin formation and lysis onto the surface of human dermal microvascular endothelial cells (H...

    Authors: O. Castillo, H. Rojas, Z. Domínguez, E. Anglés-Cano and R. Marchi

    Citation: BMC Hematology 2016 16:9

    Content type: Research article

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  41. At the time of diagnosis, Multiple Myeloma is commonly associated with renal impairment. Renal tubular acidosis without overt renal insufficiency is an uncommon disease presentation of myeloma. Among tubular a...

    Authors: Chathuranga Lakmal Fonseka, Sampath Rukshani Galappaththi, Jeewandarage Dhanushka Karunarathna, Dayakshi Dushyantha Kumarihami Abeyaratne and Nirmali Tissera

    Citation: BMC Hematology 2016 16:8

    Content type: Case report

    Published on:

  42. Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies c...

    Authors: Martha L. Louzada, Cyrus C. Hsia, Fatimah Al-Ani, Fiona Ralley, Anargyros Xenocostas, Janet Martin, Sarah E. Connelly, Ian H. Chin-Yee, Leonard Minuk and Alejandro Lazo-Langner

    Citation: BMC Hematology 2016 16:7

    Content type: Research article

    Published on:

  43. In patients hospitalized over a 4 year period for pulmonary embolism (PE), we assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in patients found to have familial-acquired thr...

    Authors: Marloe Prince, Charles J. Glueck, Parth Shah, Ashwin Kumar, Michael Goldenberg, Matan Rothschild, Nasim Motayar, Vybhav Jetty, Kevin Lee and Ping Wang

    Citation: BMC Hematology 2016 16:6

    Content type: Research article

    Published on:

  44. Mammalian erythropoiesis can be divided into two distinct types, primitive and definitive, in which new cells are derived from the yolk sac and hematopoietic stem cells, respectively. Primitive erythropoiesis ...

    Authors: Hirotada Otsuka, Jiro Takito, Yasuo Endo, Hideki Yagi, Satoshi Soeta, Nobuaki Yanagisawa, Naoko Nonaka and Masanori Nakamura

    Citation: BMC Hematology 2016 16:4

    Content type: Research article

    Published on:

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