Despite the public health significance of anaemia in African children, its broader and often preventable risk factors remain largely under described. This study investigated, for the first time, the prevalence...
Authors: Ismail Dragon Legason, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot and John Banson Barugahare
Portal hypertension has a broad differential diagnosis. POEMS syndrome is an uncommon cause of it. POEMS syndrome is a rare disease involving multiple organs. In differential diagnosis of portal hypertension, ...
Circumcision in hemophiliacs is a delicate surgery because of bleeding risks that could be avoided by adequate substitution of coagulation factor. This practice is very challenging in countries where anti hemo...
Africa is the most affected continent with 200,000 new born affected by sickle cell anemia annually with of 5% of under five deaths. Nigeria has the largest sickle cell gene pool in the world with about 2% of ...
Authors: Olorunfemi Emmanuel Amoran, Ahmed Babatunde Jimoh, Omotola Ojo and Temitope Kuponiyi
Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of t...
Authors: Anne M. Andong, Eveline D. T. Ngouadjeu, Cavin E. Bekolo, Vincent S. Verla, Daniel Nebongo, Yannick Mboue-Djieka and Simeon-Pierre Choukem
Familial and acquired thrombophilia are often etiologic for idiopathic hip and jaw osteonecrosis (ON), and testosterone therapy (TT) can interact with thrombophilia, worsening ON.
Authors: Michael Ian Jarman, Kevin Lee, Ariel Kanevsky, Sarah Min, Ilana Schlam, Chris Mahida, Ali Huda, Alexander Milgrom, Naila Goldenberg, Charles J. Glueck and Ping Wang
Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammatio...
Authors: Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang and Amal M. Saeed
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Curren...
Authors: Cristhiam M. Rojas-Hernandez, Jacklyn Nemunaitis, Kristopher D. Marjon, Daniel Bustamante, Qian-Yun Zhang and Jennifer M. Gillette
Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leu...
Authors: Tsion Sahle, Tilahun Yemane and Lealem Gedefaw
Anemia is a strong predictor of mortality and poor quality of life among persons with either renal impairment or HIV infection. In this study, we investigated the prevalence of anemia and its association with ...
Authors: Temesgen Fiseha, Zemenu Tamir, Abdurahaman Seid and Wondmagegn Demsiss
In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate ...
Authors: Muriel N. Maeder, Henintsoa M. Rabezanahary, Norosoa J. Zafindraibe, Martin Raoelina Randriatiana, Tahinamandranto Rasamoelina, Andry T. Rakotoarivo, Philippe Vanhems, Jonathan Hoffmann, Thomas Bénet, Mala Rakoto Andrianarivelo and Olivat A. Rakoto-Alson
Anaemia is one of the main factors in the deferral (disqualification) of blood donors following haematological screening. There is paucity of data on the prevalence of anaemia in blood donors in Sub-Saharan Af...
Authors: Tebit Emmanuel Kwenti and Tayong Dizzle Bita Kwenti
Hemophagocytic lymphohistiocytosis in adults is often secundary to an infection or a neoplasm. In this last case, T cell lymphomas are the most frequent causes. Hemophagocytic lymphohistiocytosis secundary to ...
Authors: El Mehdi Mahtat, Maryem Zine, Mohamed Allaoui, Malika Kerbout, Nezha Messaoudi, Kamal Doghmi and Mohamed Mikdame
Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in...
Authors: Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi and Tahir Shamsi
When availability and/or affordability of anti-hemophilic factor concentrates are limited, optimal prophylaxis regimens in severe hemophilia A (HA) remain to be determined. In selected situations, low-dose dai...
Authors: Terry Mizrahi, Jean St-Louis, Nancy L. Young, Francine Ménard, Nichan Zourikian, Evemie Dubé and Georges E. Rivard
Since the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However,...
Authors: Daniele Kazue Sugioka, Carlos Eduardo Ibaldo Gonçalves and Maria da Graça Bicalho
Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others ...
Although the demand for blood supply has progressively increased in developing countries, evidences indicate that there is a major shortage of blood and blood products in these countries, particularly in Ethio...
Authors: Yenework Acham Jemberu, Ahmed Esmael and Kedir Y. Ahmed
Anticoagulant therapy is prescribed for millions of patients worldwide for the prevention and treatment of both arterial and venous thrombosis. Historically, only vitamin K antagonists have been available for ...
Authors: Vivian Auyeung, Jignesh P. Patel, John K. Abdou, Bipin Vadher, Lynda Bonner, Alison Brown, Lara N. Roberts, Raj K. Patel and Roopen Arya
Sickle cell disease (SCD) is endemic in non-Western countries. Due to migration, the prevalence of SCD in the Netherlands has increased. Adherence to medical treatment is recognized as a major problem area. Th...
Authors: Marlous J. Madderom, Jessica Heijdra, Elisabeth M. W. J. Utens, Suzanne Polinder, Anita W. Rijneveld and Marjon H. Cnossen
Iron deficiency anemia is highly prevalent in patients with chronic kidney disease and is often treated with intravenous iron. There are few trials directly comparing the safety and efficacy of different intra...
Authors: William E. Strauss, Naomi V. Dahl, Zhu Li, Gloria Lau and Lee F. Allen
Chronic Epstein Barr virus (EBV) infection in an immunocompetent host has been described however it is not a common entity. It has been linked to many lymphoproliferative disorders and achieves such via many m...
Authors: Nawid M. Sarwari, Joseph D. Khoury and Cristhiam M. Rojas Hernandez
Bone marrow examination may be required to discriminate causes of thrombocytopenia as hypoproductive or hyperdestructive. However, this procedure is invasive and time consuming. This study assessed the diagnos...
Authors: Mikias Negash, Aster Tsegaye and Amha G/Medhin
Survival analysis is commonly used to determine the treatment effect among acute lymphoblastic leukemia (ALL) patients who undergo allogeneic stem cell transplantation (allo-SCT) or other treatments. The aim o...
Authors: Chatree Chai-Adisaksopha, Alfonso Iorio, Christopher Hillis, Wendy Lim and Mark Crowther
Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and...
Authors: C Sekaggya, D Nalwanga, A Von Braun, R Nakijoba, A Kambugu, J Fehr, M Lamorde and B Castelnuovo
