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Table 5 Disease factors and physical HRQoL of adolescents with SCD at multivariate regression analysis (adolescents and caretakers report)

From: Health-related quality of life of adolescents with sickle cell disease in sub-Saharan Africa: a cross-sectional study

Variables Physical HRQoL
Adolescents’ response
Estimate (95% CI)
P Caretakers’ response
Estimate (95% CI)
p
Malaria
 No 1.00   100  
 Yes 32.39(20.14,44.63) < 0.001 37.05(27.95,4.14) < 0.001
Hydroxyurea
 No 1.00   1.00  
 Yes −0.84(−10.98,9.29) 0.869 5.30(−5.59,16.20) 0.336
Folic acid
 No 1.00   1.00  
 Yes −28.76(− 45.41,-12.10) 0.001 − 46.17(− 65.96,-26.39) < 0.001
Pneumococcal vaccine
 No 1.00   1.00  
 Yes 28.43(16.78,40.09) < 0.001 31.37(22.22,40.51) < 0.001
Pain
 No 1.00   1.00  
 Yes −4.70(− 14.35,4.95) 0.336 − 10.02(− 19.22,-0.81) 0.033
Fever
 No 1.00   1.00  
 Yes 24.39(15.03,33.74) < 0.001 30.67(23.5,37.84) < 0.001
Stroke
 No 1.00   1.00  
 Yes 9.15(−0.75,19.05) 0.070 −29.34(−40.69,18.59) < 0.001
Blood transfusion
 None 1.00   1.00  
 1–3 6.63(−6.60,19.86) 0.323 3.48(−8.40,15.36) 0.562
 > 3 31.17(11.6.2,50.72) 0.002 24.03(8.83,39.23) 0.002