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Table 3 Distribution of the median (25th – 75th) hematological data among the βS globin haplotypes and -α3.7Kb-thalassemia

From: Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles

βS globin Haplotype 3.7Kb-Thalassemia
HbSC
(N = 52)
SCA
(N = 99)
HbSC
(N = 52)
SCA
(N = 99)
Median (25th – 75th) Median (25th – 75th) Median (25th – 75th) Median (25th – 75th) Median (25th – 75th) Median (25th – 75th) Median (25th – 75th) Median (25th – 75th)
Absence CAR
N = 26
Presence CAR
N = 26
Absence CAR
N = 29
Presence CAR
N = 70
Absence -α3.7Kb
N = 43
Presence -α3.7Kb
N = 9
Absence -α3.7Kb
N = 85
Presence -α3.7Kb
N = 14
HbS HbS Hb Hb
50.0 (48.1–51.4) 50.6 (49.5–51.6) 83.0 (76.0–88.3) 88.3 (83.5–91.7) 10.8 (10.1–11.6) 10.9 (9.9–12.4) 7.6 (7.1–8.3) 8.2 (7.3–8.8)
p = 0.301   p = 0.004   p = 0.735   p = 0.427  
HbF HbF Ht Ht
1.9 (0.8–4.5) 1.3 (0.7–3.2) 12.9 (7.5–18.3) 7.7 (4.1–11.5) 30.7 (28.7–32.5) 31.7 (28.0–34.1) 21.7 (19.9–24.1) 23.8 (21.4–25.5)
p = 0.181   p = 0.005   p = 0.961   p = 0.252  
     MCV MCV
     76.1 (71.5–80.1) 71.6 (67.3–72.4) 88.0 (83.6–93.2) 80.3 (76.3–83.1)
     p = 0.018   p < 0.001  
     MCH MCH
     27.2 (24.6–28.8) 25.0 (23.4–26.5) 30.8 (28.8–32.7) 27.7 (25.7–29.0)
     p = 0.071   p < 0.001  
  1. Hb hemoglobin, Ht hematocrit, MCV mean cell volume, MCH mean corpuscular hemoglobin. Bold values indicate significance at p < 0.05; p-value obtained using Mann-Whitney