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Table 1 Risk factors associated with direct oral anticoagulant bleeding

From: Bleeding complications from the direct oral anticoagulants

Clinical Variable

Number of patients

>80 years of age

12

Weight < 63 kg

4

Severe (<30 ml/min) or moderate (30–50 ml/min) impairment in creatinine clearance

9

Diabetes mellitus

5

Concomitant aspirin

5

Concomitant NSAIDa

5

Concomitant strong P-gpb inhibitors

3

Higher than recommended dose of dabigatran

1

  1. anon-steroidal anti-inflammatory drug
  2. bp-glycoprotein