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Table 1 Patient characteristics

From: Use of Valacyclovir for the treatment of cytomegalovirus antigenemia after hematopoietic stem cell transplantation

  All (n = 61) Valacyclovir (n = 15) Valganciclovir (n = 16) Foscarnet (n = 30) P a
Median age, years (range) 41 (16–66) 47 (18–61) 50 (30–57) 37 (16–66) 0.017
Male, N (%) 31 (50.8) 9 (60.0) 5 (31.3) 27 (56.7) 0.186
Diagnosis, N (%)      0.509
  Acute myeloid leukemia 30 (49.2) 7 (46.7) 9 (56.3) 14 (46.7)  
  Acute lymphoid leukemia 13 (21.3) 3 (20.0) 1 (6.3) 9 (30.0)  
  Non-Hodgkin’s lymphoma 2 (3.3) 1 (6.7) 1 (6.3) 0 (0.0)  
  Myelodysplastic syndrome 6 (9.8) 1 (6.7) 1 (6.3) 4 (13.3)  
  Others 10 (16.4) 3 (20.0) 4 (25.0) 3 (10.0)  
Conditioning regimen, N (%)      0.374
  Myeloabalative 32 (53.3) 9 (60.0) 11 (68.8) 12 (41.4)  
  Non-Myeloabalative 14 (23.3) 2 (13.3) 3 (18.8) 9 (31.0)  
  Reduced Intensity 14 (23.3) 4 (26.7) 2 (12.5) 8 (27.6)  
Donor type, N (%)      0.078
  Related 31 (50.8) 11 (73.3) 10 (62.5) 10 (33.3)  
  Unrelated 21 (34.4) 2 (13.3) 5 (31.3) 14 (46.7)  
  Cord Blood 9 (14.8) 2 (13.3) 1 (6.25) 6 (20.0)  
CMV serologic status, N (%)      0.586
  Donor-/recipient+ 9 (14.8) 1 (6.7) 3 (18.8) 5 (16.7)  
  Donor+/recipient+ 52 (85.3) 14 (93.3) 13 (81.3) 25 (83.3)  
GVHD (during study)      0.155
  None 27 (44.3) 5 (33.3) 4 (25.0) 18 (60.0)  
  Grade I-II 30 (49.2) 9 (60.0) 10 (62.5) 11 (36.7)  
  Grade II-IV 4 (6.6) 1 (6.7) 2 (12.5) 1 (33.3)  
GVHD treatment      0.119
  None 25 (41.0) 5 (33.3) 3 (18.8) 17 (56.7)  
  Steroids 30 (49.1) 9 (60.0) 11 (68.9) 10 (33.3)  
  Others 6 (9.8) 1 (6.7) 2 (12.5) 3 (10.0)  
Pre-treatment laboratory results, median (range)
  Creatinine (μM) 78 (40–240) 86 (46–182) 72 (44–240) 78 (40–205) 0.601
  ANC (x103/mm3) 2.6 (0.2-22.8) 2.4 (0.2-6.6) 3.6 (1.1-15.6) 1.7 (0.8-22.8) 0.093
  Platelet (x103/mm3) 64 (7–260) 98 (15–197) 68 (7–244) 32.5 (8–260) 0.053
  1. CMV, cytomegalovirus; GVHD, graft versus host disease; ANC, absolute neutrophil count
  2. aP value for difference by treatment group, based on chi-square test or analysis of variance