Table 1 Showing blood counts and chemistry profiles
From: Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia
Laboratory Findings | At Presentation | 1. month | 3. month | 5. month | 7. month | 7,5. month | 8. month |
|---|---|---|---|---|---|---|---|
(×10 9 /L) | |||||||
White Blood Cells | 4.6 | 59.0 | 170.0 | 19.0 | 149.0 | 250.0 | 315.0 |
Basophil count | 2.6 | 36.5 | 79.9 | 9.8 | 77.4 | 122.8 | |
Eosinophil count | - | - | 4.5 | 5.3 | 4.1 | - | |
Mast cell count | - | - | 28.9 | 3.0 | 23.8 | 78.7 | |
Platelet | 134.0 | 157 | 80.0 | 43.0 | 43.9 | 41.0 | |
Hgb (g/dL) | 5.7 | 8.9 | 7.1 | 8.9 | 8.9 | 7.2 | |
Manual Differential Counts (%) | |||||||
Seg. Basophil | 46 | 10 | 10 | 14 | - | ||
Basophil Band | 8 | 12 | 5 | 2 | 1 | ||
Basophil Meta. | 3 | 25 | 14 | 20 | 13 | ||
Basophil Myelo. | - | 15 | 18 | 16 | 25 | ||
Promyelocyte | - | - | 9 | - | 26 | ||
Eosinophilic series | 29 | 6 | 27 | 28 | - | ||
Myeloblast | - | - | - | - | 2 | ||
Mast cell | - | - | 17 | 16 | 25 | ||
Tryptase (μg/L) † | 42.9 | 51.2 | |||||
Histamine (nmol/L)†† | - | 1.2 | |||||
IL-6 (pg/mL) ††† | - | 38.5 | |||||
CRP (mg/dL) | - | 85.6 | 225 | 30 | 55.9 | ||
LDH (U/L) | - | 561 | 1221 | - | 5174 | ||
Treatments | Watch-wait | HU 1 g/L (×3 days) | leukaph. + HU 1.5 g/l (×3 days) + prednisolon 40 mg | İmatinib 300 mg/d + HU 0.5 g/d | leukaph. + Etoposide 50 mg | leukaph. + i.v. Cyclophos-phamide 1000 mg | EX |