Figure 1

Laboratory parameters and treatment over time. Plasma IgG (green), plasma IgA (yellow), and thrombocyte count (blue) are illustrated as percentages of reference lower limit (6.0 g/L, 0.78 g/L, and 150 × 10^⁹/L respectively). Time of Rituximab treatment (red line) and initiation of IgG substitution therapy (green arrow) are also depicted. Thrombocyte-binding IgGs identified in serum (square) or bound to the patient’s thrombocytes but undetectable in serum (diamond) are marked. Finally, time points for measurement of insufficient concentrations of pneumococcal polysaccharide-binding IgGs are marked (triangle).