Table 2 Regression model predicting aggregate bother among patients with at least one side effect

Group Mean (SD)§§

3.56

(1.00)

3.60

(0.95)

3.46

(1.03)

2.74

Adjusted R ² (N)

0.11

(208)

0.32

(128)

0.19

(130)

0.12

Age

-0.06(.00)

-0.01(.00)

-0.13(.01)

0.05(.01)

Frequency of dry bleeds (0 = No bleeds, 1 = bleeds)

-0.10(.25)

0.24(.26)

**

0.16(.29)

-0.03(.25)

Time since diagnosis¶

0.00(.12)

-0.01(.13)

0.07(.17)

0.13(.26)

Gender (0 = Male; 1 = Female)

0.10(.17)

0.09(.20)

0.06(.21)

0.05(.21)

Longest cycle duration§

-

-

-

-

Typical low platelet count (past year)

00(0)

0.25(.00)

*

-0.10(.00)

0.14(.00)

Need to stop or reduce (0 = No, 1 = Yes)

0.31(.16)

****

0.43(.17)

****

0.34(.21)

****

-

Number of treatment effects

0.15(.04)

*

0.24(.04)

**

0.23(.04)

**

0.34(.09)

Number of ITP treatments (among 5 treatment

-0.11(.05)

-0.04(.06)

0.09(.07)

-0.01(.07)

types)

Other ITP medications in combination (0 = No;

0.07(.15)

0.08(.16)

0.00(.18)

-

1 = Yes)

Time since last taking drug/procedure†

-0.02(.15)

-0.18(.19)

*

-0.11(.19)

0.01(.16)

Type of physician‡

-0.03(26)

0.11(.27)

0.07(.40)

-0.02(.24)

Frequency of wet bleeds (0 = No bleeds, 1 = bleeds)

0.07(.15)

-0.22(.16)

**

-0.16(.20)

-0.05(.21)