Table 2 Features of disease severity by HbF level
From: Foetal haemoglobin and disease severity in sickle cell anaemia patients in Kampala Uganda
Clinical features | Patients with High HbF levels (≥10%) N = 80(%) | Patients with low HbF levels (<10%) N = 136 (%) | OR (95% CI) | p value |
|---|---|---|---|---|
History of dactylitis | ||||
Present | 53 (66.3%) | 106 (77.9%) | ||
Absent | 27 (33.7%) | 30 (22.1%) | 1.80 (0.97-3.53) | 0.060 |
Age at onset of dactylitis | ||||
<1 year | 37 (69.8%) | 78 (73.6%) | ||
≥ 1 year | 16 (30.2%) | 28 (26.4%) | 1.20 (0.57-2.50) | 0.617 |
Age at diagnosis | ||||
≤ 1 year | 31 (38.8%) | 54 (40%) | ||
> 1 year | 49 (61.2%) | 81 (60%) | 1.05 (0.59-1.86) | 0.857 |
Hospitalisations in past year | ||||
No | 40 (50%) | 63 (46.3%) | 1.16 (0.67-2.02) | 0.602 |
yes | 40 (50%) | 73 (53.7%) | ||
Transfusions in past year | ||||
No | 62 (77.5%) | 92 (67.7%) | 1.65 (0.87-3.13) | 0.123 |
Yes | 18 (22.5%) | 44 (32.3%) | ||
Painful episodes in past year | ||||
No | 27 (33.7%) | 41 (30.1%) | 1.18 (0.65-2.13) | 0.583 |
Yes | 53 (66.3%) | 95 (69.9%) | ||
History of stroke | ||||
No | 76 (95%) | 123 (90.4%) | 2.00 (0.63-6.43) | 0.231 |
Yes | 4 (5%) | 13 (9.6%) |