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Table 2 Features of disease severity by HbF level

From: Foetal haemoglobin and disease severity in sickle cell anaemia patients in Kampala Uganda

Clinical features Patients with High HbF levels (≥10%) N = 80(%) Patients with low HbF levels (<10%) N = 136 (%) OR (95% CI) p value
History of dactylitis     
Present 53 (66.3%) 106 (77.9%)   
Absent 27 (33.7%) 30 (22.1%) 1.80 (0.97-3.53) 0.060
Age at onset of dactylitis     
<1 year 37 (69.8%) 78 (73.6%)   
≥ 1 year 16 (30.2%) 28 (26.4%) 1.20 (0.57-2.50) 0.617
Age at diagnosis     
≤ 1 year 31 (38.8%) 54 (40%)   
> 1 year 49 (61.2%) 81 (60%) 1.05 (0.59-1.86) 0.857
Hospitalisations in past year     
No 40 (50%) 63 (46.3%) 1.16 (0.67-2.02) 0.602
yes 40 (50%) 73 (53.7%)   
Transfusions in past year     
No 62 (77.5%) 92 (67.7%) 1.65 (0.87-3.13) 0.123
Yes 18 (22.5%) 44 (32.3%)   
Painful episodes in past year     
No 27 (33.7%) 41 (30.1%) 1.18 (0.65-2.13) 0.583
Yes 53 (66.3%) 95 (69.9%)   
History of stroke     
No 76 (95%) 123 (90.4%) 2.00 (0.63-6.43) 0.231
Yes 4 (5%) 13 (9.6%)