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Table 2 Distribution of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) genotypes and their association with the occurrence of relapse in 64 case subjects and 64 successfully treated matched control subjects with acute lymphoblastic leukemia from ALL-BFM trials 86 and 90

From: Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy

  Cases (%) Controls (%) ORa (95 % CIb) P value
TNF     
   TNF1/TNF1 41 (64.1) 43 (67.2) 1.00  
   TNF1/TNF2 21 (32.8) 20 (31.3) 1.17c (0.53-2.56) 0.697
   TNF2/TNF2 2 (3.1) 1 (1.6)   
LT-α     
   10.5 kb/10.5 kb 25 (39.1) 30 (46.9) 1.00  
   10.5 kb/5.5 kb 32 (50.0) 23 (35.9) 2.17 d (0.84-5.58) 0.107
   5.5 kb/5.5 kb 7 (10.9) 11 (17.2) 0.50 d (0.09-2.66) 0.418
  1. a odds ratio b confidence interval c odds ratio for the combined category of TNF1/TNF2 and TNF2/TNF2 genotypes d odds ratio for the combined category of LT-α (10.5 kb/5.5 kb) and LT-α (5.5 kb/5.5 kb) with reference to LT-α (10.5 kb/10.5 kb) was 1.5 (95% CI = 0.68-3.32; P = 0.317)