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Table 2 Distribution of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) genotypes and their association with the occurrence of relapse in 64 case subjects and 64 successfully treated matched control subjects with acute lymphoblastic leukemia from ALL-BFM trials 86 and 90

From: Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy

 

Cases (%)

Controls (%)

ORa (95 % CIb)

P value

TNF

    

   TNF1/TNF1

41 (64.1)

43 (67.2)

1.00

 

   TNF1/TNF2

21 (32.8)

20 (31.3)

1.17c (0.53-2.56)

0.697

   TNF2/TNF2

2 (3.1)

1 (1.6)

  

LT-α

    

   10.5 kb/10.5 kb

25 (39.1)

30 (46.9)

1.00

 

   10.5 kb/5.5 kb

32 (50.0)

23 (35.9)

2.17 d (0.84-5.58)

0.107

   5.5 kb/5.5 kb

7 (10.9)

11 (17.2)

0.50 d (0.09-2.66)

0.418

  1. a odds ratio b confidence interval c odds ratio for the combined category of TNF1/TNF2 and TNF2/TNF2 genotypes d odds ratio for the combined category of LT-α (10.5 kb/5.5 kb) and LT-α (5.5 kb/5.5 kb) with reference to LT-α (10.5 kb/10.5 kb) was 1.5 (95% CI = 0.68-3.32; P = 0.317)
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BMC Hematology

ISSN: 2052-1839

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