Figure 6
The IPA network analysis of cGVHD-SSc gene candidates. Several networks were generated for 163 cGVHD candidate genes significantly affected by new host environment in CD4+ lymphocytes. The top network is presented here and is limited to genes with direct relationships with candidates for the skin manifestation of cGVHD. Relationships between genes are represented by solid lines (binding), solid arrows (direct activation), or broken arrows (indirect activation). Arrows point to the element on which an action is performed. Black molecules represent fibroblast related genes. Grey molecules represent other significant cGVHD genes.