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  1. Research article

    Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial

    Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammatio...

    Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang and Amal M. Saeed

    BMC Hematology 2017 17:4

    Published on: 16 March 2017

  2. Case report

    Chronic lymphocytic leukemia with clinical debut as neurological involvement: a rare phenomenon and the need for better predictive markers

    Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Curren...

    Cristhiam M. Rojas-Hernandez, Jacklyn Nemunaitis, Kristopher D. Marjon, Daniel Bustamante, Qian-Yun Zhang and Jennifer M. Gillette

    BMC Hematology 2017 17:3

    Published on: 2 February 2017

  3. Research article

    Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections

    In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate ...

    Muriel N. Maeder, Henintsoa M. Rabezanahary, Norosoa J. Zafindraibe, Martin Raoelina Randriatiana, Tahinamandranto Rasamoelina, Andry T. Rakotoarivo, Philippe Vanhems, Jonathan Hoffmann, Thomas Bénet, Mala Rakoto Andrianarivelo and Olivat A. Rakoto-Alson

    BMC Hematology 2016 16:30

    Published on: 1 December 2016

  4. Case report

    Hemophagocytic lymphohistiocytosis complicating a T-cell rich B-cell lymphoma

    Hemophagocytic lymphohistiocytosis in adults is often secundary to an infection or a neoplasm. In this last case, T cell lymphomas are the most frequent causes. Hemophagocytic lymphohistiocytosis secundary to ...

    El Mehdi Mahtat, Maryem Zine, Mohamed Allaoui, Malika Kerbout, Nezha Messaoudi, Kamal Doghmi and Mohamed Mikdame

    BMC Hematology 2016 16:28

    Published on: 24 November 2016

  5. Research article

    Prevalence of transfusion transmissible infections in blood donors of Pakistan

    Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in...

    Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi and Tahir Shamsi

    BMC Hematology 2016 16:27

    Published on: 18 November 2016

  6. Research article

    Adherence to treatment regimen and bleeding rates in a prospective cohort of youth and young adults on low-dose daily prophylaxis for severe hemophilia A

    When availability and/or affordability of anti-hemophilic factor concentrates are limited, optimal prophylaxis regimens in severe hemophilia A (HA) remain to be determined. In selected situations, low-dose dai...

    Terry Mizrahi, Jean St-Louis, Nancy L. Young, Francine Ménard, Nichan Zourikian, Evemie Dubé and Georges E. Rivard

    BMC Hematology 2016 16:26

    Published on: 8 November 2016

  7. Research article

    KIR repertory in patients with hematopoietic diseases and healthy family members

    Since the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However,...

    Daniele Kazue Sugioka, Carlos Eduardo Ibaldo Gonçalves and Maria da Graça Bicalho

    BMC Hematology 2016 16:25

    Published on: 29 September 2016

  8. Study protocol

    Anticoagulated patient’s perception of their illness, their beliefs about the anticoagulant therapy prescribed and the relationship with adherence: impact of novel oral anticoagulant therapy – study protocol for The Switching Study: a prospective cohort study

    Anticoagulant therapy is prescribed for millions of patients worldwide for the prevention and treatment of both arterial and venous thrombosis. Historically, only vitamin K antagonists have been available for ...

    Vivian Auyeung, Jignesh P. Patel, John K. Abdou, Bipin Vadher, Lynda Bonner, Alison Brown, Lara N. Roberts, Raj K. Patel and Roopen Arya

    BMC Hematology 2016 16:22

    Published on: 23 August 2016

  9. Study protocol

    A randomized controlled trial studying the effectiveness of group medical appointments on self-efficacy and adherence in sickle cell disease (TEAM study): study protocol

    Sickle cell disease (SCD) is endemic in non-Western countries. Due to migration, the prevalence of SCD in the Netherlands has increased. Adherence to medical treatment is recognized as a major problem area. Th...

    Marlous J. Madderom, Jessica Heijdra, Elisabeth M. W. J. Utens, Suzanne Polinder, Anita W. Rijneveld and Marjon H. Cnossen

    BMC Hematology 2016 16:21

    Published on: 4 August 2016

  10. Research article

    Ferumoxytol versus iron sucrose treatment: a post-hoc analysis of randomized controlled trials in patients with varying renal function and iron deficiency anemia

    Iron deficiency anemia is highly prevalent in patients with chronic kidney disease and is often treated with intravenous iron. There are few trials directly comparing the safety and efficacy of different intra...

    William E. Strauss, Naomi V. Dahl, Zhu Li, Gloria Lau and Lee F. Allen

    BMC Hematology 2016 16:20

    Published on: 26 July 2016

  11. Case report

    Chronic Epstein Barr virus infection leading to classical Hodgkin lymphoma

    Chronic Epstein Barr virus (EBV) infection in an immunocompetent host has been described however it is not a common entity. It has been linked to many lymphoproliferative disorders and achieves such via many m...

    Nawid M. Sarwari, Joseph D. Khoury and Cristhiam M. Rojas Hernandez

    BMC Hematology 2016 16:19

    Published on: 19 July 2016

  12. Research article

    Diagnostic predictive value of platelet indices for discriminating hypo productive versus immune thrombocytopenia purpura in patients attending a tertiary care teaching hospital in Addis Ababa, Ethiopia

    Bone marrow examination may be required to discriminate causes of thrombocytopenia as hypoproductive or hyperdestructive. However, this procedure is invasive and time consuming. This study assessed the diagnos...

    Mikias Negash, Aster Tsegaye and Amha G/Medhin

    BMC Hematology 2016 16:18

    Published on: 1 July 2016

  13. Research article

    Challenges in achieving a target international normalized ratio for deep vein thrombosis among HIV-infected patients with tuberculosis: a case series

    Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and...

    C Sekaggya, D Nalwanga, A Von Braun, R Nakijoba, A Kambugu, J Fehr, M Lamorde and B Castelnuovo

    BMC Hematology 2016 16:16

    Published on: 4 June 2016

  14. Research article

    Prevalence of neutropenia in children by nationality

    A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the...

    Srdjan Denic, Hassib Narchi, Lolowa A. Al Mekaini, Suleiman Al-Hammadi, Omar N. Al Jabri and Abdul-Kader Souid

    BMC Hematology 2016 16:15

    Published on: 21 May 2016

  15. Study protocol

    The MUK five protocol: a phase II randomised, controlled, parallel group, multi-centre trial of carfilzomib, cyclophosphamide and dexamethasone (CCD) vs. cyclophosphamide, bortezomib (Velcade) and dexamethasone (CVD) for first relapse and primary refractory multiple myeloma

    Multiple myeloma is a plasma cell tumour with an annual incidence in the UK of approximately 40–50 per million i.e. about 4500 new cases per annum. The triple combination cyclophosphamide, bortezomib (Velcade®...

    Sarah Brown, Samantha Hinsley, Mónica Ballesteros, Sue Bourne, Paul McGarry, Debbie Sherratt, Louise Flanagan, Walter Gregory, Jamie Cavenagh, Roger Owen, Cathy Williams, Martin Kaiser, Eric Low and Kwee Yong

    BMC Hematology 2016 16:14

    Published on: 17 May 2016

  16. Research article

    Generic and disease-specific quality of life among youth and young men with Hemophilia in Canada

    This study was undertaken to explore the longitudinal patterns of health-related quality of life (HRQoL) among youth and young adults with Hemophilia A (HA) over a 3-year period. This report presents the basel...

    J. St-Louis, D. J. Urajnik, F. Ménard, S. Cloutier, R. J. Klaassen, B. Ritchie, G. E. Rivard, M. Warner, V. Blanchette and N. L. Young

    BMC Hematology 2016 16:13

    Published on: 5 May 2016

  17. Study protocol

    Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and poor prognosis due to red blood cell transfusion–dependent anemia and thrombocytopenia

    CC-486 is an oral formulation of the epigenetic modifier azacitidine. In an expanded phase 1 trial, CC-486 demonstrated clinical and biological activity in patients with International Prognostic Scoring System...

    Guillermo Garcia-Manero, Antonio Almeida, Aristoteles Giagounidis, Uwe Platzbecker, Regina Garcia, Maria Teresa Voso, Stephen R. Larsen, David Valcarcel, Lewis R. Silverman, Barry Skikne and Valeria Santini

    BMC Hematology 2016 16:12

    Published on: 3 May 2016

  18. Research article

    Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation

    Langerhans cells (LC) are bone marrow-derived cells in the skin. The LC donor/recipient chimerism is assumed to influence the incidence and severity of graft-versus-host disease (GVHD) after hematopoietic stem...

    Sabrina Peters, Christian Junghanss, Anne Knueppel, Hugo Murua Escobar, Catrin Roolf, Gudrun Knuebel, Anett Sekora, Iris Lindner, Ludwig Jonas, Mathias Freund and Sandra Lange

    BMC Hematology 2016 16:11

    Published on: 27 April 2016

  19. Research article

    Characteristics of chronic lymphocytic leukemia in Senegal

    Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL is the most common type of leukemia in Western populatio...

    Abibatou Sall, Awa Oumar Touré, Fatimata Bintou Sall, Moussa Ndour, Seynabou Fall, Abdoulaye Sène, Blaise Félix Faye, Moussa Seck, Macoura Gadji, Tandakha Ndiaye Dièye, Claire Mathiot, Sophie Reynaud, Saliou Diop and Martine Raphaël

    BMC Hematology 2016 16:10

    Published on: 23 April 2016

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