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Table 6 Disease factors and psychosocial HRQoL of adolescents with SCD at multivariate regression analysis (adolescents and caretakers report)

From: Health-related quality of life of adolescents with sickle cell disease in sub-Saharan Africa: a cross-sectional study

Variables

Psychosocial HRQoL

adolescents’ response

Estimate (95% CI)

p

Caretakers’ response

Estimate (95% CI)

p

Malaria

 Yes

38.74(31.21,46.30)

< 0.001

17.39(7.00,27.77)

< 0.001

Hydroxyurea

 Yes

−12.57(−18.80,-6.34)

< 0.001

−29.165(−41.35,-16.98)

< 0.001

Folic acid

 Yes

1.27(−8.97,11.51)

0.806

−11.62(−33.63,10.38)

0.296

Pneumococcal vaccine

 Yes

8.67(1.51,15.84)

0.018

15.94(5.50,26.38)

0.003

Pain

 Yes

−4.37(−10.30,1.56)

0.147

−29.17(−39.39,-18.94)

< 0.001

Fever

 Yes

16.06(10.30,21.01)

< 0.001

4.53(−3.48,12.56)

0.264

Stroke

 Yes

−6.78(− 12.87,-0.70)

0.029

−29.34(−40.69,18.59)

< 0.001

Blood transfusion

 1–3

13.89(5.76,22.03)

0.001

−26.46(−40.00,-12.91)

< 0.001

 > 3

−28.28(−40.30,-16.26)

< 0.001

−62.63(−79.52,-45.74)

< 0.001