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Table 6 Disease factors and psychosocial HRQoL of adolescents with SCD at multivariate regression analysis (adolescents and caretakers report)

From: Health-related quality of life of adolescents with sickle cell disease in sub-Saharan Africa: a cross-sectional study

Variables Psychosocial HRQoL
adolescents’ response
Estimate (95% CI)
p Caretakers’ response
Estimate (95% CI)
p
Malaria
 Yes 38.74(31.21,46.30) < 0.001 17.39(7.00,27.77) < 0.001
Hydroxyurea
 Yes −12.57(−18.80,-6.34) < 0.001 −29.165(−41.35,-16.98) < 0.001
Folic acid
 Yes 1.27(−8.97,11.51) 0.806 −11.62(−33.63,10.38) 0.296
Pneumococcal vaccine
 Yes 8.67(1.51,15.84) 0.018 15.94(5.50,26.38) 0.003
Pain
 Yes −4.37(−10.30,1.56) 0.147 −29.17(−39.39,-18.94) < 0.001
Fever
 Yes 16.06(10.30,21.01) < 0.001 4.53(−3.48,12.56) 0.264
Stroke
 Yes −6.78(− 12.87,-0.70) 0.029 −29.34(−40.69,18.59) < 0.001
Blood transfusion
 1–3 13.89(5.76,22.03) 0.001 −26.46(−40.00,-12.91) < 0.001
 > 3 −28.28(−40.30,-16.26) < 0.001 −62.63(−79.52,-45.74) < 0.001