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Table 5 The allele frequencies of β-thalassemia mutations in the current study compared to earlier studies from Palestine, other neighboring and some Middle Eastern countries

From: Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine

Nationality/ country Palestinians Israeli Arabs Jordan Syria Lebanon Egypt Iraqi Arabs Greece
Region WB WB WB/s Gaza
Phenotype TI TM, TI Mixeda TM, TT TI Mixed a5 TM, TT Mixeda TM TI TM, TI
No. of alleles analyzed 102 279 136 274 53 240 331 520 188 204 1179
Mutations
IVSI-6 T > C 76.5 28.7 48.5 13.1 57.7 8.3 4.8 14.4 20.2 24 7.2
IVSI-110 G > A 7.8 17.6 9.5 33.9 8.5 25 15.7 34.2 57.4 11.3 42.5
IVSII-1 G > A 6.9 2.9 4.4 11.3 15 9.1 8.6 5.3 41.2 2
Cd37 TGG > TGA 3.0 10.4 11.3 2.6 1.4 6.3 2.1   0.5
IVSI-1 G > A 2.0 9.0 4.4 21.2 10 13.5 15 9.6 2 13.2
Beta −101 C > T 2.0 0.6 0.5
IVSII-848 C > A 1.0 2.5 1.3 0.6 1.5
Cd106/107 (+G) 6.8
Cd39 C > T 4.6 2.2 9.5 2.8 4.6 13.3 0.2 2.1 0.5 16.9
Cd5 (-CT) 2.5 8.1 0.4 3.8 4.5 5 0.5 1.12
Not-genotyped 8.2 3.7 5.6 1.6 7.8 0.2
Wild 1.0   4.2    1.5
Total No. of mutations 7 17 10 15 7 19 31 20 7 22 10
References present study [2] [3] [20] [19] [24] [25] [23] [22] [21] [26]
  1. WB: West Bank region; WB/s: southern part of WB. TI: β-thalassemia intermedia; TM: β-thalassemia major; TT: β-thalassemia trait
  2. aMixed: included TM, TI and TT and/or Sickle B-thalassemia but did not specify the allele frequency in each subgroup