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Table 5 The allele frequencies of β-thalassemia mutations in the current study compared to earlier studies from Palestine, other neighboring and some Middle Eastern countries

From: Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine

Nationality/ country

Palestinians

Israeli Arabs

Jordan

Syria

Lebanon

Egypt

Iraqi Arabs

Greece

Region

WB

WB

WB/s

Gaza

Phenotype

TI

TM, TI

Mixeda

TM, TT

TI

Mixed a5

TM, TT

Mixeda

TM

TI

TM, TI

No. of alleles analyzed

102

279

136

274

53

240

331

520

188

204

1179

Mutations

IVSI-6 T > C

76.5

28.7

48.5

13.1

57.7

8.3

4.8

14.4

20.2

24

7.2

IVSI-110 G > A

7.8

17.6

9.5

33.9

8.5

25

15.7

34.2

57.4

11.3

42.5

IVSII-1 G > A

6.9

2.9

4.4

11.3

15

9.1

8.6

5.3

41.2

2

Cd37 TGG > TGA

3.0

10.4

11.3

2.6

1.4

6.3

2.1

 

0.5

IVSI-1 G > A

2.0

9.0

4.4

21.2

10

13.5

15

9.6

2

13.2

Beta −101 C > T

2.0

0.6

0.5

IVSII-848 C > A

1.0

2.5

1.3

0.6

1.5

Cd106/107 (+G)

6.8

Cd39 C > T

4.6

2.2

9.5

2.8

4.6

13.3

0.2

2.1

0.5

16.9

Cd5 (-CT)

2.5

8.1

0.4

3.8

4.5

5

0.5

1.12

Not-genotyped

8.2

3.7

5.6

1.6

7.8

0.2

Wild

1.0

 

4.2

  

1.5

Total No. of mutations

7

17

10

15

7

19

31

20

7

22

10

References

present study

[2]

[3]

[20]

[19]

[24]

[25]

[23]

[22]

[21]

[26]

  1. WB: West Bank region; WB/s: southern part of WB. TI: β-thalassemia intermedia; TM: β-thalassemia major; TT: β-thalassemia trait
  2. aMixed: included TM, TI and TT and/or Sickle B-thalassemia but did not specify the allele frequency in each subgroup