Table 2 Hematological data and frequency of thalassemia genotypes among Palestinian β-thalassemia intermedia patients
From: Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine
β- thalassemia genotypes | N (%) | XmnI SNP | α- thalassemia | Hb g/dL | Hb A2% | Hb F % |
|---|---|---|---|---|---|---|
β+/β+ | ||||||
IVS-I-6 / IVS-I-6 | 38 (74.5) | −/− | αα/ αα | 8.4 ± 1.1 | 6.4 ± 1.4 | 10.2 ± 6.2 |
IVS-I-6 / IVS-I-110 | 1 (1.96) | −/− | αIVSI(−5nt)α/ αα | 8.7 | ND | ND |
IVS-I-110 / IVS-I-110 | 3 (5.88) | −/− | α3.7/ αα (1:0:0)a | 9/11.7/9.5 | 3.3/3.2/8.5 | 1.7/6.4/17 |
Beta −101/ Beta − 101 | 1 (1.96) | −/− | αα/αα | 13.9 | 4.6 | 7.4 |
Subtotal | 43 (84.3) | |||||
β+/β° | ||||||
IVS-I-6 / Cd37 | 1 (1.96) | −/− | αα/ αα | 6.9 | 3.3 | 6.6 |
IVS-I-110 / Cd37 | 1 (1.96) | −/− | αα/ αα | 6.5 | 2.5 | 30.9 |
IVS-II-1 / IVS-II -848 | 1 (1.96) | +/− | –α3.7/ αα | 7.1 | 3 | 49.1 |
Subtotal | 3 (5.88) | |||||
β°/β° | ||||||
IVS-II-1 / IVS-II-1 | 3 (5.88) | +/+ | αα/ αα | 8.7 ± 0.86 | 2.1 ± 0.23 | 72.7 ± 7.3 |
IVS-I-1 / Cd37 | 1 (1.96) | −/− | αIVSI(−5nt)α/ αα | 8.7 | 2.9 | 46.8 |
Subtotal | 4 (7.84) | |||||
β+/βwt | ||||||
IVS-I-1 / βwt | 1 (1.96) | −/− | αα/ αααanti3.7 | ND | 3.8 | 6.3 |
Total | 51 (100) | |||||