Parameters | Sickle cell/malaria negative donors Mean ± SD | Sickle cell trait donors Mean ± SD | Asymptomatic malaria donors Mean ± SD | F | P-value |
---|---|---|---|---|---|
Baseline | |||||
 Plasma Hb | 0.00 | 0.00 | 0.00 |  |  |
 % haemolysis | 0.00 | 0.00 | 0.00 |  |  |
 LDH (U/L) | 202.45 ± 20.51 | 202.90 ± 18.91 | 173.20 ± 63.74 | 1.76 | 0.188 |
 Potassium (mmol/L) | 4.15 ± 0.70 | 4.22 ± 0.71 | 4.01 ± 1.50 | 0.39 | 0.681 |
 Sodium (mmol/L) | 138.44 ± 2.40 | 139.52 ± 2.54 | 126.37 ± 44.53 | 3.16 | 0.057 |
 Chloride (mmol/L) | 98.78 ± 1.66 | 99.88 ± 1.78 | 90.37 ± 31.87 | 2.68 | 0.085 |
Week 1 | |||||
 Plasma Hb | 0.10 ± 0.00 | 0.25 ± 0.13 | 0.20 ± 0.09 | 23.6 | 0.001* |
 % haemolysis | 0.51 ± 0.05 | 1.12 ± 0.27 | 1.01 ± 0.35 | 20.7 | 0.001* |
 LDH (U/L) | 318.36 ± 29.30 | 346.00 ± 78.68 | 370.90 ± 137.89 | 14.6 | 0.001* |
 Potassium (mmol/L) | 5.54 ± 0.41 | 7.02 ± 1.15 | 8.46 ± 0.75 | 33.6 | 0.001* |
 Sodium (mmol/L) | 134.90 ± 3.06 | 136.95 ± 2.88 | 121.09 ± 42.80 | 1.16 | 0.326 |
 Chloride (mmol/L) | 89.60 ± 3.12 | 90.53 ± 4.19 | 81.74 ± 28.74 | 1.47 | 0.246 |
Week 3 | |||||
 Plasma Hb | 0.11 ± 0.03 | 0.39 ± 0.12 | 0.23 ± 0.11 | 22.2 | 0.001* |
 % haemolysis | 0.76 ± 0.35 | 2.21 ± 0.62 | 1.37 ± 0.41 | 17.3 | 0.001* |
 LDH (U/L) | 436.36 ± 46.31 | 491.10 ± 47.17 | 605.77 ± 61.98 | 33.0 | 0.001* |
 Potassium (mmol/L) | 8.05 ± 1.39 | 12.02 ± 1.61 | 11.83 ± 1.47 | 40.3 | 0.001* |
 Sodium (mmol/L) | 130.88 ± 4.23 | 133.45 ± 3.42 | 129.00 ± 3.51 | 3.74 | 0.035 |
 Chloride (mmol/L) | 85.61 ± 3.91 | 83.37 ± 3.44 | 85.37 ± 2.85 | 0.73 | 0.487 |
Week 5 | |||||
 Plasma Hb | 0.20 ± 0.04 | 0.48 ± 0.19 | 0.28 ± 0.14 | 8.84 | 0.001* |
 % haemolysis | 1.46 ± 0.51 | 2.75 ± 1.00 | 1.78 ± 0.65 | 4.48 | 0.001* |
 LDH (U/L) | 536.09 ± 58.71 | 631.90 ± 109.29 | 798.00 ± 64.38 | 13.0 | 0.001* |
 Potassium (mmol/L) | 11.35 ± 4.46 | 19.48 ± 2.86 | 15.18 ± 1.98 | 8.25 | 0.001* |
 Sodium (mmol/L) | 127.64 ± 6.00 | 129.62 ± 5.17 | 124.73 ± 4.79 | 9.70 | 0.001* |
 Chloride (mmol/L) | 84.27 ± 4.29 | 77.81 ± 4.31 | 78.61 ± 3.44 | 1.22 | 0.309 |