RBC and RBC indices | Baseline Mean | Week 1 Mean (%∆) | Week 2 Mean (%∆) | Week 3 Mean (%∆) | Week 4 Mean (%∆) | Week 5 Mean (%∆) | P-values |
---|---|---|---|---|---|---|---|
Sickle cell and malaria negative donor blood | Â | ||||||
 RBC (×1012/L) | 4.72 | 4.27 (−9.5) | 4.08 (− 13.5) | 4.03 (− 14.6) | 3.98(−15.6) | 4.04 (− 14.4) | 0.147a |
 Hb (g/dl) | 13.17 | 11.35 (−13.8) | 10.49 (− 20.3) | 9.97 (− 24.3) | 10.06 (−23.6) | 9.74 (−26.0) | 0.022a |
 HCT (%) | 37.54 | 33.52 (−10.7) | 28.83 (− 23.2) | 28.52 (−24.0) | 28.48(− 24.1) | 28.06(− 25.2) | 0.013a |
 MCV (fL) | 75.88 | 76.99 (1.5) | 75.34 (−0.7) | 74.37 (−1.9) | 74.67 (−1.6) | 75.22 (− 0.9) | 0.952a |
 MCH (pg) | 26.70 | 26.23 (−1.7) | 27.61 (3.4) | 25.85 (−3.1) | 26.39 (−1.1) | 26.14 (−2.0) | 0.924a |
 MCHC (g/dl) | 32.47 | 31.39 (−3.3) | 33.58 (3.4) | 31.90 (−1.7) | 32.45 (−0.6) | 31.92 (−1.6) | 0.932a |
 RDW_CV (%) | 14.14 | 14.14 (0.0) | 14.20 (0.4) | 15.02 (6.2) | 14.63 (3.4) | 14.76 (4.3) | 0.486b |
 RDW_SD (fL) | 32.38 | 32.38 (0.0) | 33.55 (3.6) | 31.76 (−1.9) | 32.14 (−0.7) | 30.17 (−6.8) | 0.756b |
Sickle cell trait donor blood | |||||||
 RBC (×1012/L) | 4.75 | 4.06 (−14.5) | 3.58 (−24.6) | 3.57 (−24.8) | 3.56 (−25.0) | 3.49 (−26.5) | 0.016a |
 Hb (g/dl) | 14.45 | 12.84 (−11.1) | 12.47 (−13.7) | 11.47 (−20.6) | 11.57 (− 19.9) | 11.43 (−20.8) | 0.002a |
 HCT (%) | 39.96 | 36.75 (−8.0) | 33.34 (−16.5) | 33.29 (−16.7) | 32.55 (− 18.5) | 33.22 (− 16.8) | 0.005a |
 MCV (fL) | 82.54 | 86.71 (5.0) | 82.02 (−0.6) | 81.27 (−1.5) | 82.03 (− 0.61) | 82.95 (0.4) | 0.573a |
 MCH (pg) | 30.36 | 30.29 (−0.2) | 30.39 (0.3) | 28.54 (−5.9) | 29.12 (−4.0) | 28.43 (−6.3) | 0.424a |
 MCHC (g/dl) | 36.75 | 34.99 (−4.7) | 37.08 (0.9) | 34.96 (− 4.8) | 35.50 (−3.4) | 34.30 (−6.6) | 0.001a |
 RDW_CV (%) | 14.75 | 14.75 (0.0) | 14.91 (1.0) | 15.30 (3.7) | 15.03 (1.8) | 23.68 (60.5) | 0.518b |
 RDW_SD (fL) | 35.59 | 35.59 (0.0) | 36.54 (2.6) | 33.80 (5.0) | 34.06 (4.2) | 31.83 (10.5) | 0.082b |
Asymptomatic malaria donor blood | |||||||
 RBC (×1012/L) | 5.00 | 4.48 (−10.4) | 4.02 (−19.6) | 4.00 (−20.0) | 3.96 (−20.8) | 3.72 (−25.6) | 0.001*,a |
 Hb (g/dl) | 14.73 | 13.06 (−11.3) | 12.12 (−17.7) | 11.82 (− 19.7) | 11.98 (− 18.6) | 11.53 (−21.7) | 0.001*,a |
 HCT (%) | 42.72 | 38.83 (−9.1) | 34.04 (−20.3) | 34.32 (− 19.6) | 34.33 (−19.6) | 33.38 (−21.8) | 0.001*,a |
 MCV (fL) | 89.15 | 87.66 (−1.6) | 82.04 (−7.9) | 81.81 (−8.2) | 82.68 (−7.2) | 83.31 (−6.5) | 0.067a |
 MCH (pg) | 30.85 | 29.42 (−4.6) | 29.66 (−3.8) | 28.13 (−8.8) | 29.20 (−5.3) | 29.15 (−5.5) | 0.320a |
 MCHC (g/dl) | 35.48 | 33.57 (−5.3) | 36.22 (2.0) | 34.45 (2.9) | 35.38 (−0.2) | 35.01 (−1.3) | 0.002b |
 RDW_CV (%) | 14.81 | 14.81 (0.0) | 15.80 (6.6) | 16.39 (10.6) | 16.16 (9.1) | 16.26 (9.7) | 0.024a |
 RDW_SD (fL) | 36.53 | 36.53 (0.0) | 35.75 (−2.1) | 33.82 (−7.4) | 34.49 (−5.5) | 34.49 (−5.5) | 0.267a |