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Table 4 Coagulation parameters before and after initial dose of rFVIIa

From: Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience

 

INR (Mean ± SD)

PT (seconds) (Mean ± SD)

aPTT (seconds) (Mean ± SD)

Before

After

p-value

Before

After

p-value

Before

After

p-value

All patients (n = 76)

1.55 ± 0.42

0.97 ± 0.44

< 0.001

24.02 ± 21.79

12.50 ± 5.20

< 0.001

52.31 ± 25.13

39.48 ± 18.32

0.001

Surgical (n = 35)

1.64 ± 0.44

0.84 ± 0.47

< 0.001

24.81 ± 24.45

11.02 ± 5.49

0.003

57.84 ± 33.78

37.42 ± 20.23

0.009

Medical causes (n = 41)

1.47 ± 0.39

1.09 ± 0.39

< 0.001

23.35 ± 19.53

13.77 ± 4.63

0.006

47.60 ± 12.84

41.24 ± 16.56

0.021

  1. SD Standard deviation
  2. INR International normalized ratio; PT Prothrombin time; aPTT Activated partial thromboplastin time; rFVIIa Recombinant activated factor VII