Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?

Table 1 Recommended daily intake of vitamin C for adults

Reference	Male RDI mg/day	Female RDI mg/day	Plasma concentration μmol/L	Criteria
Garry et al. [30]	150 (elderly men)	75 (elderly women)	57^c	“If maintaining a maximum body pool is a desirable end point”
Newton et al. [31]	N/A	60 (elderly women)	20	“ensure against impairment of health”
Olson and Hodges [33]	40	30	14^b	Scurvy - “To maintain a suitable body pool”
Levine et al. [32]	200	200	66^a	“first dose beyond sigmoid part”
Carr and Frei [35]	120	120	58^b	“reduced risk of cardiovascular disease and cancer”
Institute of Medicine [38]	90	75	48^b	“80% of maximal neutrophil concentration”
FAO/WHO [39]	45	45	17^b	“A body content of 900 mg falls half way between tissue saturation and the point at which clinical signs of scurvy appear”
FAO/WHO [39]	45	45	17^b	“45 mg would achieve 50% saturation in the tissues”
Levine et al. [48]	N/A	90 (healthy young women)	48^b	“using Food and Nutrition Board guidelines”
Carr et al. [34]	120–200	120–200	58-66^a	“optimal intake of vitamin C required to maintain general health and wellbeing”
NHMRC [40]	45	45	17^b	“body content is halfway between tissue saturation and the point at which clinical signs of scurvy appear”
UK Government [49]	40	40	14^b	Not specified in reference

^amean of 7 patients, derived from Levine et al. [32]
^bestimated from Fig. 5 and table and chart in Additional file 2
^cconverted from stated concentration of 1.0 mg/dL to SI units using formula provided by Newton et al. [31]: 1.0 μmol/L ≈ 17.6 μg/100 mL

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