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Table 1 Recommended daily intake of vitamin C for adults

From: Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?

Reference Male RDI mg/day Female RDI mg/day Plasma concentration
μmol/L
Criteria
Garry et al. [30] 150 (elderly men) 75 (elderly women) 57c “If maintaining a maximum body pool is a desirable end point”
Newton et al. [31] N/A 60 (elderly women) 20 “ensure against impairment of health”
Olson and Hodges [33] 40 30 14b Scurvy - “To maintain a suitable body pool”
Levine et al. [32] 200 200 66a “first dose beyond sigmoid part”
Carr and Frei [35] 120 120 58b “reduced risk of cardiovascular disease and cancer”
Institute of Medicine [38] 90 75 48b “80% of maximal neutrophil concentration”
FAO/WHO [39] 45 45 17b “A body content of 900 mg falls half way between tissue saturation and the point at which clinical signs of scurvy appear”
“45 mg would achieve 50% saturation in the tissues”
Levine et al. [48] N/A 90 (healthy young women) 48b “using Food and Nutrition Board guidelines”
Carr et al. [34] 120–200 120–200 58-66a “optimal intake of vitamin C required to maintain general health and wellbeing”
NHMRC [40] 45 45 17b “body content is halfway between tissue saturation and the point at which clinical signs of scurvy appear”
UK Government [49] 40 40 14b Not specified in reference
  1. amean of 7 patients, derived from Levine et al. [32]
  2. bestimated from Fig. 5 and table and chart in Additional file 2
  3. cconverted from stated concentration of 1.0 mg/dL to SI units using formula provided by Newton et al. [31]: 1.0 μmol/L ≈ 17.6 μg/100 mL