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Fig. 4 | BMC Hematology

Fig. 4

From: Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?

Fig. 4

Proposed mechanisms for the influence of vitamin C status on time taken to develop folate deficiency. The double orange line indicates the site for the first proposed mechanism for the influence of vitamin C status on time taken to develop folate deficiency; vitamin C assists in the deconjugation of folylpolyglutamates to folylmonoglutamates in the intestine. The triple orange line indicates the site for the second proposed mechanism; the conversion of 5-Methyldihydrofolic acid into bio-active 5-Methyltetrahydrofolic acid in tissue cells. The dashed orange lines indicate the sites for the third proposed mechanism; reduced folates are protected from oxidation by vitamin C

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