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Table 5 Immunophenotypic alterations detected in PB monocytes from LR-MDS patients versus normal individuals (controls)

From: A pilot study on the usefulness of peripheral blood flow cytometry for the diagnosis of lower risk myelodysplastic syndromes: the “MDS thermometer”

 

LR-MDS

(n = 14)

Controls

(n = 14)

Increased CD56 expression in monocytes

 CD14+CD56+ cells (% total CD14+ monocytes) (*)

15 (0–99)

7 (0–15)

 Increased percentages of CD14+ 56+ cells (>  18.0% total CD14+ monocytes)

6 (43%)

0 (0%)

 Severity

  Mild: CD56+ cells]18%–23%]

1 (7%)

0 (0%)

  Moderate: CD56+ cells [23%–28%]

1 (7%)

0 (0%)

  Severe: CD56+ cells]28%–100%]

4 (29%)

0 (0%)

Decreased CD16 expression in monocytes

 CD14+CD16+ cells (% total CD14+ monocytes) (**)

3 (0–8)

12 (4–28)

 Decreased percentages of CD14+CD16+ cells (<  5.0% of total CD14+ monocytes)

9 (64%)

2 (14%)

 Severity

  Mild: CD16+ cells [2.5%–5.0%]

2 (14%)

2 (14%)

  Moderate: CD16+ cells [1.25–2.5%]

1 (7%)

0 (0%)

  Severe: CD16+ cells [0.00–1.25%]

6 (43%)

0 (0%)

  1. Abbreviations: LR-MDS lower risk myelodysplastic syndromes, PB peripheral blood
  2. Results are expressed as absolute and (relative) frequencies or as median (range) values
  3. Percentages were approximated to the closest full unit
  4. Mann-Whitney U test, LR-MDS patients versus controls: (*) P = 0.026; (**) P < 0.001