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Table 1 Hematologic assessment of patient

From: Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia

Parameters Patients Reference values
Blood count   
White blood cells (103/μl) 5.8 4–11
Red blood cells (106/μl) 2.47 4.5–5.7
Hemoglobin (g/dl) 7.1 13–17
Mean corpuscular volume (fl) 83 80–100
Mean Corpuscular Hemoglobin (pg) 28.9 27–32
Mean Corpuscular Hemoglobin Concentration (%) 34.9 32–36
Absolute reticulocyte count (ARC) (/μl) 60,800 *
Platelets (103/μl) 22 150–450
Blood smear   
Circulating plasma cells (%) 49 0
Bone marrow smear   
Bone marrow plasma cells (%) 90 0–2
Hemostasis assessment   
First-line screening tests for hemostasis   
APTT (seconds) 72 36…44
Prothrombin time (%) 87 70–100
Fibrinogen levels (g/L) 2.88 2–4
Bleeding Time - 3 points Ivy Method (minutes) 2.5 2–4
Exploration of prolonged APTT   
Index of circulating anticoagulants   
Without incubation   
APTT Patient (seconds) 70.8 33….41
APTT Mixed (Patient + Normal) (seconds) 40.6 33….41
APTT Normal (seconds) 33.0 33….41
Index of circulating anticoagulants (%) 10.7 > 15
After 2 h incubation at 37 °C.   
APTT Patient (seconds) 110.5 33….41
APTT Mixed (Patient + Normal) (seconds) 85.5 33….41
APTT Normal (seconds) 44.3 33….41
Index of circulating anticoagulants (%) 37.2 > 15
Diluted Russell Viper Venom time   
Normalized ratio:
(DRVV screen ratio)/ (DRVV confirm ratio)
0.99 <  1.20
Determination of coagulation factors activities Patient Patient + Normal Reference values
Factor II 61% 79% 70….120%
Factor IX 175% 127% 60….150%
Factor X 74% 64% 70…..120%
Factor XII 102% 123% 60….150%
Factor VIII 728% 379% 60….150%
VWF: Ag 438% 344% 50…..160%
Factor XI 13% 10% 60….150%
  1. *=ARC< 120,000/μl: non-regenerative anemia and ARC> 120,000/μl: regenerative anemia APTT = Activated partial thromboplastin time, VWF: Ag = VWF: Von willebrand factor antigen, DRVVT: dilute Russell viper venom time, Patient +Normal: mixing the patient’s plasma in equal parts with a pool of normal plasma