Table 1 Hematologic assessment of patient
From: Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia
Parameters | Patients | Reference values | |
|---|---|---|---|
Blood count | |||
White blood cells (103/μl) | 5.8 | 4–11 | |
Red blood cells (106/μl) | 2.47 | 4.5–5.7 | |
Hemoglobin (g/dl) | 7.1 | 13–17 | |
Mean corpuscular volume (fl) | 83 | 80–100 | |
Mean Corpuscular Hemoglobin (pg) | 28.9 | 27–32 | |
Mean Corpuscular Hemoglobin Concentration (%) | 34.9 | 32–36 | |
Absolute reticulocyte count (ARC) (/μl) | 60,800 | * | |
Platelets (103/μl) | 22 | 150–450 | |
Blood smear | |||
Circulating plasma cells (%) | 49 | 0 | |
Bone marrow smear | |||
Bone marrow plasma cells (%) | 90 | 0–2 | |
Hemostasis assessment | |||
First-line screening tests for hemostasis | |||
APTT (seconds) | 72 | 36…44 | |
Prothrombin time (%) | 87 | 70–100 | |
Fibrinogen levels (g/L) | 2.88 | 2–4 | |
Bleeding Time - 3 points Ivy Method (minutes) | 2.5 | 2–4 | |
Exploration of prolonged APTT | |||
Index of circulating anticoagulants | |||
Without incubation | |||
APTT Patient (seconds) | 70.8 | 33….41 | |
APTT Mixed (Patient + Normal) (seconds) | 40.6 | 33….41 | |
APTT Normal (seconds) | 33.0 | 33….41 | |
Index of circulating anticoagulants (%) | 10.7 | > 15 | |
After 2 h incubation at 37 °C. | |||
APTT Patient (seconds) | 110.5 | 33….41 | |
APTT Mixed (Patient + Normal) (seconds) | 85.5 | 33….41 | |
APTT Normal (seconds) | 44.3 | 33….41 | |
Index of circulating anticoagulants (%) | 37.2 | > 15 | |
Diluted Russell Viper Venom time | |||
Normalized ratio: (DRVV screen ratio)/ (DRVV confirm ratio) | 0.99 | < 1.20 | |
Determination of coagulation factors activities | Patient | Patient + Normal | Reference values |
Factor II | 61% | 79% | 70….120% |
Factor IX | 175% | 127% | 60….150% |
Factor X | 74% | 64% | 70…..120% |
Factor XII | 102% | 123% | 60….150% |
Factor VIII | 728% | 379% | 60….150% |
VWF: Ag | 438% | 344% | 50…..160% |
Factor XI | 13% | 10% | 60….150% |