Table 4 Comparison of the laboratory data between SCA and HbSC patients
Laboratory value | SCA (N = 98) Median (25th – 75th) | HbSC (N = 52) Median (25th – 75th) | p value |
|---|---|---|---|
Hemolysis | |||
RBC, ×1012/L | 2.60 (2.30–2.80) | 4.15 (3.80–4.50) | <0.001 |
Hemoglobin, g/dL | 7.60 (7.15–8.50) | 10.90 (10.12–11.82) | <0.001 |
Hematocrit, % | 21.80 (20.15–24.47) | 30.80 (28.72–32.50) | <0.001 |
MCV, fL | 86.05 (81.37–91.10) | 74.40 (70.80–79.72) | <0.001 |
MCH, fL | 30.15 (27.87–32.25) | 26.60 (24.60–28.67) | <0.001 |
RDW, fL | 24.80 (21.60–27.20) | 18.65 (17.62–19.57) | <0.001 |
Total bilirubin, mg/dL | 2.55 (1.67–3.72) | 1.20 (0.80–1.67) | <0.001 |
Direct bilirubin, mg/dL | 0.45 (0.30–0.60) | 0.30 (0.20–0.40) | <0.001 |
Indirect bilirubin, mg/dL | 2.20 (1.20–3.12) | 0.90 (0.52–1.27) | <0.001 |
LDH, U/L | 1094.00 (785.50–1684.50) | 481.50 (381.75–567.25) | <0.001 |
Reticulocyte | |||
Reticulocyte count | 5.40 (4.20–8.20) | 3.65 (2.62–4.37) | <0.001 |
NO metabolites | |||
NOm, μM | 35.62 (28.02–47.50) | 31.34 (23.19–40.80) | 0.047 |
Leukocytes | |||
WBC, × 109/L | 13.80 (11.17–16.10) | 10.45 (7.22–12.90) | <0.001 |
Segment count, × 109/L | 5778.00 (4275.25–7203.50) | 5182.00 (3498.50–6717.00) | 0.080 |
Eosinophil count, × 109/L | 695.50 (281.50–1774.75) | 421.50 (216.50–895.25) | 0.007 |
Lymphocyte count, × 109/L | 5535.00 (4335.00–7156.50) | 3356.50 (2492.00–4704.75) | <0.001 |
Monocyte count, × 109/L | 349.50 (219.00–670.75) | 257.00 (144.50–402.75) | 0.003 |
Platelets | |||
Platelet count, ×103/mL | 441.50 (365.25–547.00) | 267.00 (189.50–389.00) | <0.001 |
MPV, fL | 9.50 (8.80–10.40) | 9.70 (9.30–10.40) | 0.314 |
Lipid metabolism | |||
Total Cholesterol, mg/dL | 122.00 (97.75–146.75) | 133.50 (110.25–166.75) | 0.012 |
HDL-C, mg/dL | 32.00 (27.00–38.00) | 37.00 (33.00–44.75) | <0.001 |
LDL-C, mg/dL | 67.00 (41.75–88.25) | 73.00 (57.00–109.75) | 0.071 |
VLDL-C, mg/dL | 22.00 (16.75–31.25) | 21.00 (14.00–27.75) | 0.178 |
Triglycerides, mg/dL | 110.00 (82.75–156.50) | 103.50 (68.50–138.50) | 0.175 |