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Table 4 Comparison of the laboratory data between SCA and HbSC patients

From: Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles

Laboratory value SCA (N = 98)
Median (25th – 75th)
HbSC (N = 52)
Median (25th – 75th)
p value
Hemolysis
 RBC, ×1012/L 2.60 (2.30–2.80) 4.15 (3.80–4.50) <0.001
 Hemoglobin, g/dL 7.60 (7.15–8.50) 10.90 (10.12–11.82) <0.001
 Hematocrit, % 21.80 (20.15–24.47) 30.80 (28.72–32.50) <0.001
 MCV, fL 86.05 (81.37–91.10) 74.40 (70.80–79.72) <0.001
 MCH, fL 30.15 (27.87–32.25) 26.60 (24.60–28.67) <0.001
 RDW, fL 24.80 (21.60–27.20) 18.65 (17.62–19.57) <0.001
 Total bilirubin, mg/dL 2.55 (1.67–3.72) 1.20 (0.80–1.67) <0.001
 Direct bilirubin, mg/dL 0.45 (0.30–0.60) 0.30 (0.20–0.40) <0.001
 Indirect bilirubin, mg/dL 2.20 (1.20–3.12) 0.90 (0.52–1.27) <0.001
 LDH, U/L 1094.00 (785.50–1684.50) 481.50 (381.75–567.25) <0.001
Reticulocyte
 Reticulocyte count 5.40 (4.20–8.20) 3.65 (2.62–4.37) <0.001
NO metabolites
 NOm, μM 35.62 (28.02–47.50) 31.34 (23.19–40.80) 0.047
Leukocytes
 WBC, × 109/L 13.80 (11.17–16.10) 10.45 (7.22–12.90) <0.001
 Segment count, × 109/L 5778.00 (4275.25–7203.50) 5182.00 (3498.50–6717.00) 0.080
 Eosinophil count, × 109/L 695.50 (281.50–1774.75) 421.50 (216.50–895.25) 0.007
 Lymphocyte count, × 109/L 5535.00 (4335.00–7156.50) 3356.50 (2492.00–4704.75) <0.001
 Monocyte count, × 109/L 349.50 (219.00–670.75) 257.00 (144.50–402.75) 0.003
Platelets
 Platelet count, ×103/mL 441.50 (365.25–547.00) 267.00 (189.50–389.00) <0.001
 MPV, fL 9.50 (8.80–10.40) 9.70 (9.30–10.40) 0.314
Lipid metabolism
 Total Cholesterol, mg/dL 122.00 (97.75–146.75) 133.50 (110.25–166.75) 0.012
 HDL-C, mg/dL 32.00 (27.00–38.00) 37.00 (33.00–44.75) <0.001
 LDL-C, mg/dL 67.00 (41.75–88.25) 73.00 (57.00–109.75) 0.071
 VLDL-C, mg/dL 22.00 (16.75–31.25) 21.00 (14.00–27.75) 0.178
 Triglycerides, mg/dL 110.00 (82.75–156.50) 103.50 (68.50–138.50) 0.175
  1. RBC red blood cells, MCV mean cell volume, MCH mean corpuscular hemoglobin, RDW red cell distribution width, LDH lactate dehydrogenase, NOm: nitric oxide metabolites, WBC white blood cell, MPV mean platelet volume, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, VLDL-C very low-density lipoprotein cholesterol; Bold values indicate significance at p < 0.05; p-value obtained using Mann-Whitney