Fig. 1
From: A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion
Transformed electrospray TOF spectra of fibrinogen Aα chains. a Normal control homozygote for the Aα Thr312 allele, (b) father, (c) proband. The father showed a normal Aα312Thr chain at 66,134 Da with a new variant chain at 66,080 Da containing an Arg → Cys mutation (−53 Da). The proband, who had no normal Aα312Thr chains, was heterozygous for the new variant and an Aα312Ala chain (66,108 Da) inherited from her mother. Peaks at +80 Da reflect successive Ser-phosphorylation. The Y- axis depicts a relative voltage response in arbitrary units