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Table 1 Coagulation abnormalities in 240 patients with primary osteonecrosis, compared with 110 healthy normal controls

From: Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy

Coagulation measures

Abnormal range

Primary ON (n = 240)

Normal controls (n = 110)

Case vs control p a

Factor V Leiden

TC, TT

21/235 (9%)

2/109 (2%)

.014

Prothrombin gene

TC, TT

9/228 (4%)

3/110 (3%)

.76 (F)

MTHFR

TT

46/226 (20%)

32/109 (29%)

.068

PAI-1 gene

4G4G

66/225 (29%)

26/104 (25%)

.42

Homocysteine

Dated cut pointb

32/212 (15%)

5/107 (5%)

.0061

ACLA IgG

Dated cut pointc

11/210 (5%)

6/109 (6%)

.92

ACLA IgM

Dated cut pointd

27/209 (13%)

2/109 (2%)

.0011

Lupus anticoagulant

positive

2/203 (1%)

2/110 (2%)

.61 (F)

Lp(a)

≥35 mg/dl

61/205 (30%)

21/107 (20%)

.054

Factor VIII

>150%

47/175 (27%)

7/103 (7%)

<.0001

Factor XI

>150%

15/169 (9%)

3/101 (3%)

.060

Protein C

<73%

10/204 (5%)

6/96 (6%)

.63

Protein S

<63%

1/206 (0.5%)

4/96 (4%)

.037 (F)

Free S

<66%

8/186 (4%)

2/96 (2%)

.50 (F)

Antithrombin III

<80

8/203 (4%)

2/96 (2%)

.51 (F)

   

Compare with 72 controls

 

eNOS

TC, TT

90/138 (65%)

28/72 (29%)

.0003

  1. acomparisons made by Chi-square test, unless there were cells which had expected counts <5 in 2 × 2 table where Fisher’s exact test (F) was used
  2. bdated cut point for Homocysteine high: ≥15 (11/15/08-12/2/14); ≥10.4 (after 12/3/14)
  3. c dated cut point for IgG high: ≥23 GPL (before 10/31/12); ≥15 (after 11/1/12)
  4. d dated cut point for IgM high: ≥10 MPL (before 4/30/12); ≥13 (after 5/1/12)
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BMC Hematology

ISSN: 2052-1839

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