From: Hemophagocytic lymphohistiocytosis complicating a T-cell rich B-cell lymphoma
≥ five of the eight criteria listed below: | |
---|---|
Fever | |
Splenomegaly | |
Cytopenias (affecting at least two of three lineages in the peripheral blood): • Hemoglobin < 9 g/dl • Platelets < 100 G/mm3 • Neutrophils <1 G/mm3 | |
Hypertriglyceridemia (fasting, 265 mg/100 ml) and/or hypofibrinogenemia (150 mg/100 ml) | |
Hemophagocytosis in bone marrow, spleen or lymph nodes | |
Ferritin ≥ 500 ng/ml | |
Low or absent Natural Killer cell activity | |
Soluble IL-2 receptor ≥ 2400 U/ml |