Table 4 Mean change in TSAT and serum ferritin over time by CKD stage
CKD Stage | TSAT, % (SD) | Ferritin, μg/L (SD) | ||
|---|---|---|---|---|
Ferumoxytol Treatment Group | Iron Sucrose Treatment Group | Ferumoxytol Treatment Group | Iron Sucrose Treatment Group | |
Stage 1 (eGFR ≥90 mL/min) | (n = 280) | (n = 126) | (n = 280) | (n = 126) |
Baseline | 5.8 (11.25) | 4.3 (5.21) | 14.1 (39.76) | 15.4 (53.11) |
Week 2 | 26.1 (19.59) | 15.8 (11.90) | 291.1 (192.69) | 172.5 (245.93) |
Week 3 | 24.1 (11.54) | 19.8 (15.38) | 179.7 (157.02) | 157.3 (211.08) |
Week 4 | 22.7 (10.95) | 19.2 (13.81) | 123.7 (124.20) | 124.0 (211.93) |
Week 5 | 22.9 (21.75) | 19.1 (14.77) | 98.3 (118.96) | 96.4 (185.27) |
Stage 2 (eGFR 60 to <90 mL/min) | (n = 104) | (n = 59) | (n = 104) | (n = 59) |
Baseline | 6.6 (5.7) | 5.1 (3.47) | 55.4 (138.26) | 22.7 (80.21) |
Week 2 | 26.2 (11.41) | 25.8 (51.56) | 442.0 (398.63) | 215.0 (226.93) |
Week 3 | 24.3 (10.39) | 17.2 (7.81) | 325.6 (385.93) | 196.6 (212.70) |
Week 4 | 23.9 (11.17) | 18.9 (12.46) | 277.9 (394.82) | 166.2 (254.32) |
Week 5 | 22.5 (10.35) | 16.5 (6.66) | 247.2 (471.24) | 127.5 (214.99) |
Stage 3 (eGFR 30 to <60 mL/min) | (n = 41) | (n = 33) | (n = 41) | (n = 33) |
Baseline | 13.4 (18.31) | 16.1 (22.18) | 106.6 (168.37) | 106.5 (157.15) |
Week 2 | 26.6 (13.27) | 21.8 (22.81) | 629.3 (507.21) | 338.6 (296.76) |
Week 3 | 25.0 (11.45) | 18.9 (8.16) | 518.1 (425.74) | 373.0 (321.68) |
Week 4 | 23.2 (11.01) | 19.2 (7.78) | 452.5 (443.14) | 314.8 (284.35) |
Week 5 | 23.1 (12.15) | 19.4 (7.86) | 426.0 (433.68) | 312.0 (284.41) |
Stage 4 (eGFR 15 to <30 mL/min) | (n = 23) | (n = 20) | (n = 23) | (n = 20) |
Baseline | 21.7 (19.41) | 17.0 (6.49) | 152.3 (123.03) | 141.4 (158.16) |
Week 2 | 30.6 (9.71) | 24.3 (7.14) | 720.7 (280.38) | 520.2 (244.56) |
Week 3 | 28.6 (13.22) | 24.0 (5.85) | 632.8 (324.78) | 529.6 (244.92) |
Week 4 | 32.2 (15.81) | 25.7 (7.18) | 552.4 (327.53) | 440.5 (228.45) |
Week 5 | 26.3 (6.34) | 23.1 (5.79) | 514.6 (285.12) | 407.0 (231.30) |
Stage 5 (eGFR <15 mL/min) | (n = 38) | (n = 42) | (n = 38) | (n = 42) |
Baseline | 22.3 (12.91) | 21.7 (14.76) | 411.3 (348.97) | 359.7 (287.65) |
Week 2 | 34.6 (16.18) | 25.4 (12.87) | 915.8 (372.92) | 603.4 (338.87) |
Week 3 | 32.2 (12.81) | 24.7 (7.44) | 959.0 (605.92) | 675.2 (339.54) |
Week 4 | 30.4 (12.57) | 27.7 (13.27) | 831.7 (452.94) | 682.2 (391.21) |
Week 5 | 28.7 (8.82) | 27.9 (15.80) | 788.4 (427.21) | 618.9 (355.47) |