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Table 5 Coagulation disorders in 24 cases (6 men [on testosterone] and 18 women [on estrogen]) who had testosterone/hormone therapy before PE, compared to 116 cases with PE but no hormone, no cancer (62 men, 54 women), and compared to 17 cancer cases (9 men, 8 women)

From: Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia

 

Factor VIII

Factor XI

Protein C

Protein S

Free S

Antithrombin III

Abnormal range

> 150 %

> 150 %

< 73 %

< 63 %

< 66 %

< 80

Hormone Cases (n = 24,

6 men on TT,

18 women on ET)

3/24

(13 %)

1/23

(4 %)

2/24

(8 %)

5/24

(21 %)

4/24

(17 %)

3/24

(13 %)

PE_no hormone, no Cancer (n = 116, 62 men, 54 women)

  

27/90

(30 %)*

8/77

(10 %)

11/74

(15 %)

8/80

(10 %)

Cancer (n = 17,

9 men, 8 women)

  

1/16

(6 %)

1/16

(6 %)

 

1/14

(7 %)

  1. * p < .05, comparing with Hormone cases by Fisher’s test