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Fig. 6 | BMC Hematology

Fig. 6

From: The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate

Fig. 6

Extramedullary erythropoiesis in newly identified structures. a Macroscopic observation of the abdominal cavity. Wine-colored structures were observed in the omentum in splenectomized mice that were treated with both NBP and PHZ (arrow). b The histological analysis stained with H-E. Numerous hematopoietic cells including megakaryocytes (arrow), were observed in these structures. c Immunohistochemical detection of TER119-positive cells. Most of the cells in this structure were TER119-positive erythroblasts. d RT-PCR analysis to determine globin mRNA levels in these newly identified structures. Both adult and embryonic globin mRNAs were expressed. Bars show 25 μm (b, c)

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BMC Hematology

ISSN: 2052-1839

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