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Fig. 5 | BMC Hematology

Fig. 5

From: The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate

Fig. 5

The expression of erythropoiesis-related transcription factors in the BM and liver. a The expression levels of erythropoiesis-related factors (Gata1, Klf1 and Klf2) were up-regulated in the BM and liver after treatment with both NBP and PHZ (NBP + PHZ), but no change was observed in the expression of Bcl11a. b ChIP-PCR analysis of KLF1 and KLF2 promoter-binding region. KLF1 and KLF2 promoter-binding regions were detected using PCR amplification in splenectomized mice that were treated with NBP and PHZ but not in control animals. Genomic DNA (gDNA) was used as a positive control. NC indicates results of PCR performed without primers. Rabbit IgG was used as a negative control for ChIP

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BMC Hematology

ISSN: 2052-1839

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