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Fig. 1 | BMC Hematology

Fig. 1

From: The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate

Fig. 1

Experimental schedule and the analysis of peripheral blood. a The schema of the experimental schedule. Blood sample were collected every day (gray arrowhead), and tissue samples were obtained at 5 days after NBP injection (white arrowhead). Arrows indicate the time of the treatment (control, NBP alone, PHZ alone or NBP + PHZ). b The hematocrit values of all groups at 5 days after treatment. No change was observed by treatment with NBP alone, significant reduction were observed by PHZ treatment. Moreover, serious anemia was induced in the animals treated with both NBP and PHZ (NBP + PHZ). c The hematocrit values in the control animals and the animals treated with both NBP and PHZ (NBP + PHZ). Treatment with PHZ and NBP resulted in a significant reduction in hematocrit values after PHZ injection, which occurred 3 days after the NBP injection was detected. d The EPO concentration in the serum. The PHZ and NBP group (PHZ + NBP) had significantly increased EPO concentrations compared to the control. The error bars indicate the standard error of the mean (SEM)

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