Table 1 Population demographics by age group

Number, %

160 (73)

60 (27)

-

Median age (IQR), yrs

26.8 (21.9;32.4)

48.3 (43.7;52.6)

-

Baseline FVIII:C, no. (%)

  <1%

119 (74)

46 (77)

NS

  1%

25 (16)

10 (17)

NS

  2%

16 (10)

4 (6)

NS

Time records available

  Median (IQR), yrs

11.2 (4;19)

18.7 (11.1;28.8)

<0.001

  Range, yrs

0.5-38

0.5-48

Inhibitor status no. (%) ¹

  Historical*

23 (15)

15 (25)

NS

  Current

2 (1)

6 (10)

0.002

Joints affected, median no. (%)

  0-1

79 (49)

15 (25)

<0.001

  2-4

73 (46)

31 (52)

<0.001

  >4

8 (5)

14 (23)

<0.001

Prior Joint procedures, no.

  Median

0 (0;1)

1 (0;3)

<0.001

  Range

0-4

0-8

Co-infections, no. (%)

  HIV

40 (25)

35 (58)

<0.001

  HCV Ab

89 (56)

48 (80)

0.001

  HCV RNA+

50 (31)

31 (52)

0.005

  HIV + HCV Ab

36 (23)

29 (48)

<0.001

  HIV + HCV RNA+

27 (17)

22 (37)

0.002

  HBSAg +

11 (7)

4 (7)

NS

Median weight (IQR), kg

79.5 (69.5;88.5)

71.5 (63.5;79)

0.002