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Table 1 Population demographics by age group

From: Prophylaxis in older Canadian adults with hemophilia A: lessons and more questions

  18-39 years ≥40 years p value
Number, % 160 (73) 60 (27) -
Median age (IQR), yrs 26.8 (21.9;32.4) 48.3 (43.7;52.6) -
Baseline FVIII:C, no. (%)    
  <1% 119 (74) 46 (77) NS
  1% 25 (16) 10 (17) NS
  2% 16 (10) 4 (6) NS
Time records available    
  Median (IQR), yrs 11.2 (4;19) 18.7 (11.1;28.8) <0.001
  Range, yrs 0.5-38 0.5-48  
Inhibitor status no. (%) 1    
  Historical* 23 (15) 15 (25) NS
  Current 2 (1) 6 (10) 0.002
Joints affected, median no. (%)    
  0-1 79 (49) 15 (25) <0.001
  2-4 73 (46) 31 (52) <0.001
  >4 8 (5) 14 (23) <0.001
Prior Joint procedures, no.    
  Median 0 (0;1) 1 (0;3) <0.001
  Range 0-4 0-8  
Co-infections, no. (%)    
  HIV 40 (25) 35 (58) <0.001
  HCV Ab 89 (56) 48 (80) 0.001
  HCV RNA+ 50 (31) 31 (52) 0.005
  HIV + HCV Ab 36 (23) 29 (48) <0.001
  HIV + HCV RNA+ 27 (17) 22 (37) 0.002
  HBSAg + 11 (7) 4 (7) NS
Median weight (IQR), kg 79.5 (69.5;88.5) 71.5 (63.5;79) 0.002
  1. 1Data missing for 2 subjects. *Includes transient and current inhibitors.