Figure 4

Pathway analysis of cGVHD specific transcripts in CD4 ⁺ lymphocytes. 210 cGVHD transcripts were analyzed by the Ingenuity Pathway Analysis (IPA) software. IPA mapped 163 of these transcripts to known genes and identified three major processes associated with cGVHD: connective tissue development and function (solid bars), skeletal and muscular system development function (open bars), and immune cell trafficking (hatched bars). The height of each bar represents − log₁₀P value (y axis) of corresponding biological function (x axis). The dashed line indicates the P value = 0.05 (−log₁₀P = 1.301).