Figure 1

eGWAS for aSCT and SSc using a χ ² analysis. The significance, P values, of each tested gene is expressed as − log₁₀ (y axis) and plotted against corresponding chromosomal location (x axis). P values for each gene were calculated for 7 microarray datasets (4 aSCT and 3 SSc) as the likelihood of finding repeated differential expression compared with expected using χ ² analysis. Out of 32671 genes tested 118 genes demonstrated a significant differential expression, of which 101 had the known chromosomal location. The dotted line indicates the Bonferroni threshold (P = 1.53 × 10⁻⁶). The gene symbols indicate genes that are most significantly associated with both clinical aSCT and SSc. The open circles represent genes that demonstrated significant changes in both diseases and the solid circles represent genes with significant changes only in one of tested diseases. Underscored symbols indicate known cGVHD genes. * - genes that were also detected by subtraction of ranking order gene lists.