Table 2 Comparison of number of cases, age and sex distribution and four most common causes of pancytopenia in different studies conducted in different countries
Study | Country | Year | No. of cases | Age group | M : F ratio | Commonest cause | 2nd common cause | 3rd common cause | 4th common cause |
|---|---|---|---|---|---|---|---|---|---|
Kale P et al.[6] | India | 1991 | 70 | All | - | HS (47.6%) | MA (25.4%) | AL (14.5%) | Infections (7.25%) |
Tilak and Jain et al.[4] | India | 1999 | 77 | 5 to 70 | 1.1 : 1 | MA (68%) | AA (7.7%) | Other causes (24.3%) | Â |
Savage et al.[7] | Zimbabwe | 1999 | 134 | All | - | MA | AA | AL | AIDS |
Kumar et al.[5] | India | 2001 | 166 | 12 - 73 | 2.1 : 1 | AA (29.5%) | MA (22.3%) | Aleukemic leukemia (12%) | HS (11.4%) |
Iqbal W et al.[8] | Pakistan | 2001 | 208 | All | - | MA (28.3%) | AA (22.1%) | HS (14.4%) | NHL (5.3%) |
Khunger et al.[9] | India | 2002 | 200 | 2 - 70 | 1.2 : 1 | MA (72%) | AA (28%) | Subleukemic leukemia (5%) | HS (3%) |
Niazi M. et al.[10] | Pakistan | 2004 | 89 | 1 - 75 | 1.7 : 1 | BM Aplasia (38.3%) | MA (24.7%) | HS (18.4%) | AL (13.6%) |
Ishtiaq O et al.[3] | Pakistan | 2004 | 100 | 12 - 82 | 1.1 : 1 | MA (39%) | HS (19%) | AA and HA (10%) | MDS (5%) |
Hamid et al. [11] | Yemen | 2008 | 75 | 3 - 85 | 1.03 : 1 | HS (45.3%) | MA (14.7%) | AA (13.3%) | AL (13.3%) |
P. M. devi et al.[12] | India | 2008 | 50 | 3 - 80 | 1.5 : 1 | HA (22%) | MA (18%) | MDS (18%) | Subleukemic leukemia (14%) |
Jalbani A. et al.[13] | Pakistan | 2009 | 40 | 12 - 70 | 2.6 : 1 | AA (32.5%) | HS (22.5%) | MA (15%) | NHL (10%) |
Tariq M. et al.[14] | Pakistan | 2010 | 50 | 15 - 70 | 1.7 : 1 | AA (36%) | MA (16%) | MDS (14%) | ALL (12%) |
Santra G. et al.[15] | India | 2010 | 111 | 13 - 65 | 1.5 : 1 | AA (22.72%) | HS (15%) | DI (13%) | KA (9%) |
Aziz T. et al.[16] | Pakistan | 2010 | 88 | 15 - 60 | 2.6 : 1 | MA (40.9%) | AA (31.9%) | HS and CM (11.4%) | AL (10%) |
Ashraf S. et al.[17] | Pakistan | 2010 | 150 | 15 - 60 | 1.1 : 1 | HS (68%) | MA (25.4%) | HM (6.6%) | Â |
Gayathri B. N. et al.[18] | India | 2011 | 104 | 2 - 80 | 1.2 : 1 | MA (74.04%) | AA (18.3%) | Subleukemic leukemia (3.8%) | Malaria (2%) |
Vandana R. et al.[19] | India | 2012 | 80 | 1 - 79 | 1 : 1.2 | MA (41.2%) | DA (8.7%) | AA / HA (8.7%) | AL (7.5%) |
Present study | India | Â | 250 | All | 2.6 : 1 | HS (29.2%) | Infections (25.6%) | Myelosuppressants (16.8%) | MA (13.2%) |