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Table 2 Comparison of number of cases, age and sex distribution and four most common causes of pancytopenia in different studies conducted in different countries

From: An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital

Study Country Year No. of cases Age group M : F ratio Commonest cause 2nd common cause 3rd common cause 4th common cause
Kale P et al.[6] India 1991 70 All - HS (47.6%) MA (25.4%) AL (14.5%) Infections (7.25%)
Tilak and Jain et al.[4] India 1999 77 5 to 70 1.1 : 1 MA (68%) AA (7.7%) Other causes (24.3%)  
Savage et al.[7] Zimbabwe 1999 134 All - MA AA AL AIDS
Kumar et al.[5] India 2001 166 12 - 73 2.1 : 1 AA (29.5%) MA (22.3%) Aleukemic leukemia (12%) HS (11.4%)
Iqbal W et al.[8] Pakistan 2001 208 All - MA (28.3%) AA (22.1%) HS (14.4%) NHL (5.3%)
Khunger et al.[9] India 2002 200 2 - 70 1.2 : 1 MA (72%) AA (28%) Subleukemic leukemia (5%) HS (3%)
Niazi M. et al.[10] Pakistan 2004 89 1 - 75 1.7 : 1 BM Aplasia (38.3%) MA (24.7%) HS (18.4%) AL (13.6%)
Ishtiaq O et al.[3] Pakistan 2004 100 12 - 82 1.1 : 1 MA (39%) HS (19%) AA and HA (10%) MDS (5%)
Hamid et al. [11] Yemen 2008 75 3 - 85 1.03 : 1 HS (45.3%) MA (14.7%) AA (13.3%) AL (13.3%)
P. M. devi et al.[12] India 2008 50 3 - 80 1.5 : 1 HA (22%) MA (18%) MDS (18%) Subleukemic leukemia (14%)
Jalbani A. et al.[13] Pakistan 2009 40 12 - 70 2.6 : 1 AA (32.5%) HS (22.5%) MA (15%) NHL (10%)
Tariq M. et al.[14] Pakistan 2010 50 15 - 70 1.7 : 1 AA (36%) MA (16%) MDS (14%) ALL (12%)
Santra G. et al.[15] India 2010 111 13 - 65 1.5 : 1 AA (22.72%) HS (15%) DI (13%) KA (9%)
Aziz T. et al.[16] Pakistan 2010 88 15 - 60 2.6 : 1 MA (40.9%) AA (31.9%) HS and CM (11.4%) AL (10%)
Ashraf S. et al.[17] Pakistan 2010 150 15 - 60 1.1 : 1 HS (68%) MA (25.4%) HM (6.6%)  
Gayathri B. N. et al.[18] India 2011 104 2 - 80 1.2 : 1 MA (74.04%) AA (18.3%) Subleukemic leukemia (3.8%) Malaria (2%)
Vandana R. et al.[19] India 2012 80 1 - 79 1 : 1.2 MA (41.2%) DA (8.7%) AA / HA (8.7%) AL (7.5%)
Present study India   250 All 2.6 : 1 HS (29.2%) Infections (25.6%) Myelosuppressants (16.8%) MA (13.2%)
  1. HS: Hypersplenism; MA: Megaloblastic anemia; AA: Aplastic Anemia; AL: Acute leukemia; HA: Hypoplastic anemia; BM: Bone marrow; DI: Drug induced; KA: Kala-azar; CM: Chronic malaria; HM: Hypoplastic marrow; NHL: Non-Hodgkin’s lymphoma; MDS: Myelodysplastic syndrome; ALL: Acute lymphoblastic leukemia; DA: Dimorphic Anemia.