Total blood lymphocyte counts in hemochromatosis probands with HFEC282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes

Table 2 Mean total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity

HLA	log_e lymphocyte count (cells/mm³ × 10^-3 (SD))	lymphocyte count (cells/mm³ × 10^-3 (95% CI))¹	p value (present vs. absent)²
A*01 present	1.012 (0.213)	2.8 (1.8, 4.2)	0.0362
A*01 absent	1.101 (0.184)	3.0 (2.1, 4.3)
B*08 present	0.975 (0.178)	2.7 (1.9, 3.8)	0.0048
B*08 absent	1.104 (0.189)	3.0 (2.1, 4.4)
B*14 present	1.160 (0.180)	3.2 (2.2, 4.5)	0.0317
B*14 absent	1.065 (0.192)	2.9 (2.0, 4.2)
A01-B08 present	0.943 (0.195)	2.6 (1.8, 3.8)	0.0026
A01-B08 absent	1.101 (0.185)	3.0 (2.1, 4.3)

¹Lymphocyte counts were measured at diagnosis of hemochromatosis, and are expressed as mean (95% CI) after computing antilogs_e of the transformed data.
²Comparisons were made using log_e lymphocyte counts and student t-test (two-tail); p values < 0.05 were defined as significant.

ISSN: 2052-1839