Table 2 Clinical characteristics of patients in studies included in the meta-analysis
First Author | Number of patients with hepatic iron information | Treatment & mean dose (mg/kg/day) | Initial ferritin level, mean (SD) (μg/L) | Hepatic iron concentration, Mean (SD) | Measurement unit | |
|---|---|---|---|---|---|---|
Initial | Final | |||||
Hoffbrand AV | 4 | DFO 57† | 10,683 (NA) | 76.7 (30.4) | 56.9 (42.9) | μg/mg dry |
Janka GE | 2 | DFO 103§ | 3,294 (1,462)* | 26.9 (16.0) | 9.9 (5.5) | g/kg dry |
Aldouri MA | 12 | DFO 50‡ | 5,885 (3,245)* | 2945 (900) | 857 (435) | μg/100 mg dry, chemical |
Maurer HS | 12 | DFO 85§ | 3,164 (1,321)* | 3,275.5 (1,225.1)¶ | 1508.3 (887.3) | μg/100 mg dry |
Olivieri NF | 21 | L1 75 | 3,975 (3,510) | 81.9 (51.6) | 46.7 (26.4) | μmol/g wet |
Olivieri NF | 37 | L1 75 | NA | L1: 8.9 (1.2) | L1: 13.7 (1.2) | mg/g dry |
DFO 37 | DFO: 6.9 (0.9) | DFO: 7.9 (1.3) | ||||
Longo F | 52 | L1 75 | 1,897 (NA) | 1430 (NA) | 2029 (NA) | μg/g |
Mazza P | 20 | L1 70 | 4,495 (2,644) | 16.1 (12.4) | 20.4 (20.0) | mg/g dry |
Olivieri NF | 18 | L1 75 | 4,455 (3,569) | 89.1 (50.8) | 65.4 (33.5) | μmol/g wet |
Tondury P | 9 | L1 82‡ | 2,862 (1,390)** | 7.6 (4.4) | 8.9 (5.6) | mg/g dry |
Diav-Citrin O | 19 | L1 75 | 3,122 (NA) | 14.3 (7.2) | 10.0 (6.1) | mg/g dry |