From: Factors regulating Hb F synthesis in thalassemic diseases
Group of patients | N. cases | Hb g/dl | Hb F % | EPO mU/l | Glob. synth. alpha/non-alpha | Ret. ‰ |
---|---|---|---|---|---|---|
Sub-silent beta thal int | 33 | 10.1 ± 1.0 | 20.5 ± 18.2 3.0 → .70.6 | 41.22 ± 32.00 11.66 → 136.6 | 2.10 | 31 |
Evident beta thal int | 41 | 8.3 ± 1.16 | 33.40 ± 28.04 6.80 → 85.0 | 95.83 ± 64.33 17.84 → 218.97 | 2.20 | 60 |
beta thal int in double heterozygous beta thal + triplicated alpha | 58 | 10.0 ± 1.38 | 5.15 ± 3.9 2.0 → 19.3 | 28.45 ± 17.11* 7.85 → 60.72 | 2.50 | 30 |
Hb H disease | 15 | 9.4 ± 1.2 | < 1 | 32.88 ± 12.11** | 0.52 | 28 |
Thal major | 24 | 10.4 ± 1.0 | 7.7 ± 8.5*** 1.60 → 40.9 | 46.83 ± 40.78 9.82 → 129.59 | 17 | |
Healthy non-thal subjects | 53 | 14.4 ± 1.1 | <1 | 11.90 ± 3.3 | ~1.0 | 3 |
Iron-deficient non-thal subjects | 42 | 8.7 ± 1.2 | <1 | 160.10 ± 312.6 2.7 → 1960.0 | 8 |