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Table 2 ZFN targeting and cleaving within the adjacent 8,954 bp to the 5′ end of the hemoglobin, beta ( β A )-gene

From: Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study

Zinc Finger Nuclease (ZFN)

Left Fn; triplet- α-Helix

Right Fn; triplet- α-Helix

ZFN-unknown-SP-6-1

  

5′_4231 aGCCACCACCTTCT GATAGGCAGCCt 4256_′3

F1; VPSKLKR; (GGC)

F1; DPSTLRR; (GCC)

5′_4231 tCGGTGGTGGAAGA CTATCCGTCGGa 4256_′3

F2; EAHHLSR; (GGT)

F2; QSTTLKR; (GCA)

 

F3; IRHHLKR; (GGT)

F3; RRDGLAG; (TAG)

ZFN-unknown-SP-6-2

  

5′_4234 cACCACCTTCTGAT AGGCAGCCTGCa 4259_′3

F1; MKHHLAR; (GGT)

F1; RGRNLEM; (TGC)

5′_4234 gTGGTGGAAGA CTATCCGTCGGACGt 4259_′3

F2; EAHHLSR; (GGT)

F2; DSSVLRR; (GCC)

 

F3; QDGNLTR; (GAA)

F3; QGGTLRR; (GCA)