Figure 3

Schematics of ZFN-cleavage sites within the adjacent 8,954 bp to the 5′ end of the hemoglobin, beta gene. This figure graphically illustrates the cleavage sites of five ZFNs targeting sequences within 8,954 bp located to the 5′ end of the β ^A chain gene. Two of the ZFNs cleaving closest to the 5′ end of the β ^A chain-gene are shown in Table 2. Hits (blue, green, and gold bars) represent targets along the gene (red bars). ZFN hits in the graphic are color-coded based on spacer size (5 bp = Blue; 6 bp = Green; 7 bp = Gold).