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Table 3 Impact of disease and treatment on patient day-to-day limitation

From: Patient-reported treatment burden of chronic immune thrombocytopenia therapies

 

Occupation or Job

Daily activities

Lifestyle

Group Mean (SD)

2.11

(1.35)

2.25

(1.24)

2.45

(1.25)

Adjusted R 2 (N)

0.17

(512)

0.17

(512)

0.18

(512)

Age

0.03(.04)

 

0.12(.04)

**

0.06(.04)

 

AntiD aggregate bother interaction †

0.20(.05)

****

0.16(.04)

***

0.14(.04)

**

CS aggregate bother interaction †

0.12(.04)

**

0.11(.04)

*

0.09(.04)

*

IVIg aggregate bother interaction †

0.21(.05)

****

0.15(.05)

**

0.17(.05)

**

Rituximab aggregate bother interaction †

0.17(.05)

***

0.12(.05)

*

0.12(.05)

*

Splenectomy aggregate bother interaction †

0.20(.05)

***

0.19(.05)

***

0.17(.05)

***

Frequency of dry bleeds (0 = No bleeds, 1 = bleeds)

0.05(.05)

 

0.13(.05)

**

0.15(.05)

**

Time since last taking drug/procedure§

0.02(.04)

 

-0.04(.04)

 

-0.02(.04)

 

Gender (0 = male; 1 = female)

-0.06(.04)

 

-0.06(.04)

 

-0.05(.04)

 

Typical low platelet count (past year)

-0.12(.06)

*

-0.12(.06)

*

-0.11(.05)

*

Number of ITP treatments (among 5 treatment types)

-0.17(.07)

**

-0.12(.07)

 

-0.09(.04)

 

Type of physician ‡

-0.05(.04)

 

0.04(.04)

 

0.00(.05)

 

Frequency of wet bleeds (0 = No bleeds, 1 = bleeds)

0.13(.05)

**

0.13(.05)

**

0.17(.04)

***

  1. * P <0.05
  2. * *P <0.01
  3. * **P <0.001
  4. * ***P <0.0001
  5. Each model based on all patients. Patients with no side effects for a given treatment type were coded as 1.
  6. † Interaction term = Aggregate bother (1-5) × treatment received (0,1)
  7. ‡ Type of physician referred to generalist or specialist
  8. § Categorical variable were 0 = Currently taking (Less than 5 years ago in case of splenectomy), 1 = Taken in the past (5 or more years ago in case of splenectomy)