From: Foetal haemoglobin and disease severity in sickle cell anaemia patients in Kampala Uganda
Characteristic | Patients with High HbF levels (≥10%) N = 80(%) | Patients with low HbF levels (<10%) N = 136 (%) | OR (95% CI) | p value |
---|---|---|---|---|
Demographic features | ||||
Gender | ||||
Female | 48(60%) | 67(49.3%) | 1.54 (0.88-2.71) | 0.128 |
Male | 32(40%) | 69(50.7%) | ||
Age | ||||
<5 years | 28 (35%) | 20 (14.7%) | 3.12 (1.58 -6.17) | 0.0005 |
≥ 5 years | 52 (65%) | 116 (85.3%) | ||
HISTORY | ||||
Reason for clinic visit | ||||
Sick visit | 63(77%) | 100 (73.5%) | 1.33 (0.69-2.57) | 0.390 |
Routine visit | 17 (23%) | 36 (26.5%) | ||
Duration of follow up in SCC | ||||
< 5 years | 54 (67.5%) | 52 (38.2%) | 3.36 (1.83-6.16) | <0.001 |
≥ 5 year | 26 (32.5%) | 84 (61.8%) | ||
Transfusions since birth | ||||
<3 | 58 (72.5%) | 83 (61%) | 1.68 (0.91-3.08) | 0.080 |
≥ 3 | 22(27.5%) | 53 (39%) | ||
Hospitalisations since birth | ||||
≤2 | 48 (60%) | 61(55%) | 1.82 (1.03- 3.21) | 0.036 |
>2 | 32 (40%) | 75 (45%) | ||
SIGNS | ||||
Jaundice | ||||
present | 53(66.3%) | 85 (62.5%) | 1.18 (0.66-2.11) | 0.580 |
absent | 27 (33.7%) | 51 (37.5%) | ||
Palpable spleen | ||||
Yes | 24 (30%) | 28 (20.6%) | 1.65 (0.87-3.13) | 0.119 |
No | 56 (60%) | 108 (79.4%) | ||
Hepatomegaly | ||||
Present | 40 (50%) | 60 (44.1%) | 1.27 (0.73-2.21) | 0.404 |
absent | 40 (50%) | 76 (55.9%) | ||
Haematological parameters | ||||
WBC count | ||||
<15.0 | 35 (43.8%) | 65 (47.8%) | 1.18 (0.67-2.05) | 0.566 |
≥ 15.0 | 45 (56.2%) | 71 (52.2%) | ||
RBC count | ||||
<3.0 | 48 (60%) | 80 (58.8%) | 1.05 (0.60-1.85) | 0.865 |
≥ 3.0 | 32 (40%) | 56 (41.2%) | ||
Hb level | ||||
≥7 g/dl | 60 (75%) | 98 (72.1%) | 1.16 (0.62-2.19) | 0.638 |
<7 g/dl | 20 (25%) | 38 (27.9%) | ||
PLT level | ||||
<400 | 40 (50%) | 66 (48.5% | 1.06 (0.61-1.85) | 0.835 |
≥400 | 40 (50%) | 70 (51.5%) |