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Table 1 Demographic and Haematological Characteristics of the Sickle Cell Anaemia Patients

From: Serum levels of leptin in Nigerian patients with sickle cell anaemia

   SCA Patients
Parameter Control Total Steady Unsteady
No. of cases 22 55 31 24
Sex, Male/Female 10/12 25/30 16/15 9/15
Age, yr 13.0 ± 1.5 15.3 ± 1.1 17.1 ± 1.6* 13.2 ± 1.1
aHbF, % 1.3 ± 0.06 3.8 ± 0.2** 4.2 ± 0.2* 3.3 ± 0.2
Hb, g/dL 11.9 ± 0.2 8.3 ± 0.2** 8.9 ± 0.2* 7.4 ± 0.3
PCV, % 35.2 ± 0.5 25.5 ± 0.5** 27.3 ± 0.5* 23.2 ± 0.7
RC, % 1.7 ± 0.1 5.8 ± 0.3** 6.3 ± 0.4* 5.3 ± 0.6
% ICI ND 6.7 ± 0.3 5.3 ± 0.3* 8.4 ± 0.4
MCHC, g/dL 34.0 ± 0.5 32.4 ± 0.2** 32.8 ± 0.3* 31.7 ± 0.2
MCH, pg 27.4 ± 0.5 23.9 ± 0.4** 25.0 ± 0.4* 22.6 ± 0.6
MCHC < 31 g/dL, n(%) 0(0) 10 (18.2) 3 (9.7)* 7 (29.2)
MCH < 25 pg, n(%) 3 (13.6) 35 (63.6)** 16 (51.6)* 19 (79.2)
ESR, mm/Hr 14.4 ± 3.5 35.1 ± 1.0** 25.7 ± 1.1* 38.4 ± 1.3
WBC, cells/uL × 103 6.1 ± 0.2 11.7 ± 0.1** 11.4 ± 0.2* 12.1 ± 0.1
Neutrophils, cells/uL × 103 3.4 ± 0.1 7.6 ± 0.1** 7.2 ± 0.2* 8.1 ± 0.2
Lymphocytes, cells/uL × 103 2.0 ± 0.09 2.6 ± 0.1** 2.6 ± 0.1 2.4 ± 0.1
Monocytes, cells/uL × 103 0.5 ± 0.04 1.0 ± 0.06** 0.9 ± 0.08 1.2 ± 0.09
Eosinophils, cells/uL × 103 0.2 ± 0.02 0.4 ± 0.03** 0.5 ± 0.04* 0.3 ± 0.04
Basophils, cells/uL × 103 0.08 ± 0.01 0.2 ± 0.02 0.1 ± 0.02 0.2 ± 0.04
Platelet count, cells/uL × 103 241.8 ± 11.6 432.8 ± 82.6** 438.7 ± 11.1* 371.5 ± 16.2
RBC count, cells/uL × 106 4.4 ± 0.07 3.5 ± 0.05** 3.6 ± 0.04* 3.3 ± 0.07
  1. Data are expressed as mean ± SEM or number (%). aHbF was evaluated in 10 control subjects. *P < 0.05 (Steady vs. Unsteady SCA patients); **P < 0.05 (Total SCA patients vs. Control) by Student's t-test or Chi-Square (χ2) analysis; P < 0.05 was considered to be significant.