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Table 5 Quality of life scores of child self-report classified by clinical characteristics of the patients

From: Factors affecting health-related quality of life in Thai children with thalassemia

   Child self-report
   Total summary score Physical health Psychosocial health Emotional functioning Social functioning School functioning
   Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
Diagnosis (n = 310)
   β-thalassemia n = 165 76.23(11.99) 77.46(13.20) 74.74(13.20) 76.03(17.36) 83.60(15.57) 67.06(14.92)
   Homozygous β-thalassemia n = 15 71.81(10.83) 73.54(13.91) 71.89(12.89) 70.00(16.58) 80.00(13.70) 62.67(15.68)
   Hb H n = 130 77.54(10.72) 79.49(14.68) 76.63(12.28) 76.23(15.76) 84.04(13.67) 69.23(17.19)
P-value 0.145 0.187 0.234 0.368 0.424 0.103
Age at onset of anemia <2 and age at first transfusion <4 years old (n = 241)
   Yes n = 75 72.75(11.33) 73.96(15.95) 73.51(12.64) 74.53(14.71) 78.53(17.10) 63.26(14.94)
   No n = 166 77.72(11.08) 79.01(14.67) 76.02(12.73) 76.08(15.99) 85.49(13.45) 69.52(16.15)
P-value 0.002 0.023 0.099 0.228 0.003 0.003
Complications (n = 314)       
   Yes n = 19 77.52(14.37) 77.14(19.05) 77.81(16.21) 76.32(19.57) 84.21(16.52) 72.63(15.13)
   No n = 295 76.60(11.22) 78.30(14.50) 75.34(12.52) 75.83(16.46) 83.66(14.66) 67.56(15.97)
P-value 0.773 0.941 0.169 0.628 0.661 0.228
Having a severe condition* (n = 314)      
   Yes n = 113 74.07(12.05) 75.97(15.93) 74.12(12.77) 75.53(15.27) 78.89(16.86) 63.73(16.98)
   No n = 201 78.10(10.79) 79.49(15.93) 76.26(12.71) 76.04(17.37) 86.39(12.68) 69.63(15.09)
P-value 0.004 0.077 0.097 0.417 <0.001 0.021
Serum ferritin level (n = 127)      
   <2500 ng/mL n = 79 76.50(12.83) 78.20(15.66) 75.25(13.38) 74.18(18.70) 84.24(15.19) 66.27(14.82)
   >2500 ng/mL n = 48 76.61(10.14) 76.88(13.03) 75.76(12.73) 80.42(14.39) 84.06(13.94) 64.89(15.38)
P-value 0.0897 0.426 0.903 0.100 0.726 0.741
Pre-transfusion Hb level 3 months prior to QOL assessment (n = 265)    
   <7 g/dL n = 49 73.51(13.06) 75.06(17.84) 73.82(13.41) 74.03(14.21) 76.84(16.64) 64.90(18.78)
   7-9 g/dL n = 159 75.59(11.09) 77.10(14.61) 73.78(13.21) 87.01(13.09) 84.03(14.08) 66.00(15.55)
   >9 g/Dl n = 57 79.82(10.21) 81.03(13.35) 79.18(17.44) 76.49(17.44) 87.01(13.09) 74.03(14.21)
   P-value 0.012 0.163 0.016 0.474 0.002 0.008
  1. * Patients whose age at onset <2 and age at first transfusion <4 years, and/or patients diagnosed with homozygous β-thalassemia, and/or patients with a pre-transfusion Hb level lower than 7 g/dL